8.51221

PyAOP

for peptide synthesis, Novabiochem^®

• 别名: PyAOP, (7-Azabenzotriazol-1-yloxy)trispyrrolidinophosphonium hexafluorophosphate
• 经验公式（希尔记法）: C₁₇H₂₇F₆N₇OP₂
• CAS号: 156311-83-0
• 分子量: 521.38
• MDL號碼: MFCD03703417
• 分類程式碼代碼: 12352101
• NACRES: NA.22

属性

• 产品名称: PyAOP, Novabiochem^®
• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: powder
• 反應適用性: reaction type: Coupling Reactions
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 儲存溫度: 15-25°C
• SMILES 字串: F[P-](F)(F)(F)(F)F.[P](=[N+]5CCCC5)(N4CCCC4)(N3CCCC3)O[n]1nnc2c1nccc2
• InChI: 1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1
• InChI 密鑰: CBZAHNDHLWAZQC-UHFFFAOYSA-N

说明

一般說明

PyAOP is an extremely effective coupling reagent that mediates amide bond formation with the efficiency of HATU but without the risk of guanidine formation, making it the reagent of choice for peptide cyclization.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references:
^[1] F. Albericio, et al. (1997) Tetrahedron Lett., 38, 4853.

應用

PyAOP can be used as a coupling reagent:

• In the synthesis of N,N′-substituted acylguanidines by solid-phase peptide synthesis.
• To facilitate the formation of peptide bonds during the synthesis of cyclic peptide hybrids.

分析報告

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315 - H319 - H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable