28745-M

Adenosine 3′,5′-cyclic Monophosphate, N⁶,O2′-Dibutyryl-, sodium salt

≥95% (HPLC), lyophilized solid, PKA activator, Calbiochem^®

• 别名: 腺苷3′，5′-环一磷酸，N⁶，O^2′--二丁酰基-，钠盐
• 经验公式（希尔记法）: C₁₈H₂₃N₅O₈P · Na
• CAS号: 16980-89-5
• 分子量: 491.37
• MDL號碼: MFCD00005843
• 分類程式碼代碼: 41106305
• NACRES: NA.77

属性

• product name: 腺苷 3′,5′-环单磷酸，N⁶,O^2′二丁基-，钠盐, This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: water: 1 mg/mL
• 儲存溫度: −20°C
• InChI: 1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1
• InChI 密鑰: KRBZRVBLIUDQNG-JBVYASIDSA-M

说明

一般說明

Sodium N-6,2′-O-dibutyryl adenosine-3′,5′-cyclic phosphate (DBcAMP) can stimulate the production of several cytokines, such as interleukin-6 (IL-6), IL-8, and transforming growth factor-β, by keratinocytes and fibroblasts. It can accelerate neovascularization in wound healing, potentially by increasing the accumulation of endothelial progenitor cells (EPC) at wound sites. DBcAMP plays a key role in inducing various biological effects, including cell proliferation, differentiation, and migration. Dibutyryl-cAMP (db-cAMP) can prevent acute pulmonary vascular injury induced by endotoxin and attenuate ischemia/reperfusion injury in rat lungs. It inhibits fibroblast proliferation and collagen production. DBcAMP also exhibits anti-fibrotic effects in vitro and in vivo.

生化／生理作用

主要靶标
PKA

警告

毒性：标准处理（A）

重構

复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。储备水溶液在4°C下可稳定保存3天，在-20°C下可稳定保存3个月。防止pH >8.5。

其他說明

Noveen, A., et al. 1996.Biochem.Biophys.Res. Commun.219, 180.
Tsai, C.H., et al. 1995.J. Cell.Physiol.164, 108.
Leszczynski, D., et al. 1994.Am. J. Pathol.145, 1265.
Miller, C., et al. 1994.J. Neurosci. Res.38, 56.
Hinko, A., and Soloff, M.S.1993.Endocrinology 132, 126.
Ikeda, K., et al. 1993.J. Biol. Chem. 268, 1174.
Park, E.A., et al. 1993.J. Biol. Chem.268, 613.
Hei, Y-J., et al. 1991.Mol.Pharmacol.39, 233.
Posternak, T., and Weimann, G. 1974.Methods Enzymol.38, 399.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable