product name
呋塞米,
生物源
synthetic (organic)
化驗
≥98% (HPLC)
形狀
powder
mp
220 °C (dec.) (lit.)
溶解度
acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
起源
Sanofi Aventis
儲存溫度
room temp
SMILES 字串
NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
InChI
1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
InChI 密鑰
ZZUFCTLCJUWOSV-UHFFFAOYSA-N
基因資訊
human ... ALB(213) , CYP1A2(1544) , SLC12A1(6557)
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一般說明
Furosemide is a an ototoxic high-ceiling diuretic.
應用
Furosemide has been used:
- to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
- to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
- as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)
生化／生理作用
"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.
Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.
抑制肾脏中离子的协同运输。
特點和優勢
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 4 Oral - Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
其他客户在看
Furosemide
Saunders Handbook of Veterinary Drugs - E-Book (2016)
Causes of acquired hearing loss
Eggermont J J
Hearing Loss: Causes, Prevention, and Treatment (2017)
Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection
Fernandes V T and Lin V YW
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-rhino-laryngologie et de Chirurgie Cervico-Faciale, 43(1), 12-12 (2014)
Comparison of arterial pressure and plasma AngII responses to three methods of subcutaneous AngII administration
Kuroki M T, et al.
American Journal of Physiology. Heart and Circulatory Physiology (2014)
Diuretics
Side Effects of Drugs Annual, 28, 233-243 (2005)
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