所有图片(2)
About This Item
线性分子式:
C18H23N5O8PNa
CAS号:
分子量:
491.37
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥97% (HPLC)
形狀
powder
雜質
≤0.5% cyclic AMP and 2′-O-monobutyryl-cyclic AMP
≤3% N6-monobutyryl-cyclic AMP
顏色
white
溶解度
H2O: 100 mg/mL
儲存溫度
−20°C
SMILES 字串
[Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC
InChI
1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1
InChI 密鑰
KRBZRVBLIUDQNG-JBVYASIDSA-M
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相关类别
一般說明
二丁酰环磷酸腺苷(cAMP)具有类似内源性cAMP的活性。具有亲脂性，细胞渗透性更强，更能抵抗cAMP磷酸二酯酶的水解。二丁酰cAMP可抑制磷酸二酯酶，作为探针在信号转导通路中发挥重要作用。
應用
N6,2′-O-二丁酰基腺苷3′,5′-环磷酸钠盐已用于：
- 用作神经rest干细胞（NCSCs）分化的培养基补充剂
- 用作低温保存人iPSC（诱导多能干细胞）分化神经元解冻培养基的成分
- 无血清杜氏改良eagle′s培养基(DMEM)，诱导星形胶质细胞分化
可作为分化培养基组分，用于底板祖细胞分化诱导为多巴胺神经元。也作为DMEM:F12培养基补充剂，用于人多能干细胞来源的神经元细胞培养。
生化／生理作用
细胞通透性 cAMP 类似物，可激活 cAMP 依赖性蛋白激酶 (PKA)。
特點和優勢
该化合物是环核苷酸研究的特色产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
注意
在 pH 8.5 下会失去 2′-O-丁酰基
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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