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Key Documents

R2156

Sigma-Aldrich

Relaxin-1 human

recombinant, expressed in E. coli, >95% (SDS-PAGE), lyophilized powder

Synonym(s):

RLN1, RLXH1, Relaxin 1

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About This Item

CAS Number:
2222237-37-6
UNSPSC Code:
12352202
NACRES:
NA.26

biological source

human

Quality Level

100

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

(Contains two disulfide-linked subunits: A chain ~2.8 kDa B chain ~3.3 kDa)

technique(s)

cell culture | mammalian: suitable

suitability

endotoxin tested

UniProt accession no.

P04808

storage temp.

−20°C

Gene Information

human ... RLN1(6013)

General description

Cell signaling hormone that is prominent in the prostate, and belongs to the insulin superfamily

Biochem/physiol Actions

Relaxin 1 may function in regulating blood pressure, controlling heart rate, and releasing oxytocin and vasopressin
Relaxin has been shown to have antifibrotic effects in renal fibroblasts through mechanisms that increase collagenase activity and via TGF-β signaling.

Physical form

Lyophilized powder containing BSA

Reconstitution

In Phosphate buffered saline solution containing at least 0.1% serum albumin. The concentration should be ≥10 μg/mL

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rosemary Masterson et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 19(3), 544-552 (2004-02-10)
Renal fibroblasts are important effector cells in tubulointerstitial fibrosis, with experimental antifibrotic strategies focusing on the functional down-regulation of these cells. Several experimental models of fibrosis have provided evidence for the effectiveness of the polypeptide hormone relaxin as a potential

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