L8912

L-Leucine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

• Synonym(s): (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid
• Linear Formula: (CH₃)₂CHCH₂CH(NH₂)CO₂H
• CAS Number: 61-90-5
• Molecular Weight: 131.17
• Beilstein/REAXYS Number: 1721722
• EC Number: 200-522-0
• MDL number: MFCD00002617
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24896510
• NACRES: NA.26

Properties

• product name: L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
• biological source: non-animal source
• Quality Level: 300
• agency: USP/NF; meets EP testing specifications; meets JP testing specifications; meets USP testing specifications
• assay: 98.5-101.0%
• form: powder
• optical activity: [α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl; [α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl
• quality: meets EP, JP, USP testing specifications
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• color: white
• mp: >300 °C (lit.)
• solubility: 1 M HCl: 50 mg/mL
• cation traces: As: ≤1 ppm; Fe: ≤10 ppm; NH₄⁺: <0.02%; heavy metals: ≤10 ppm
• application(s): peptide synthesis; pharmaceutical (small molecule)
• functional group: amine; carboxylic acid
• storage temp.: room temp
• SMILES string: CC(C)C[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
• InChI key: ROHFNLRQFUQHCH-YFKPBYRVSA-N

Description

General description

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.

Application

L-Leucine has been used:

• as a hypertrophic agent to monitor its effects on myotubes.
• as a component of PMG media for culturing yeast.
• in myotube protein synthesis analysis in skeletal muscle cells.
• to study its effects on hepatic lipid metabolism.

Biochem/physiol Actions

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue. Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)