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270784

Sigma-Aldrich

4-(Chloromethyl)benzoyl chloride

97%

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About This Item

Linear Formula:
ClCH2C6H4COCl
CAS Number:
876-08-4
Molecular Weight:
189.04
EC Number:
212-881-0
MDL number:
MFCD00053224
UNSPSC Code:
12352100
PubChem Substance ID:
24856399
NACRES:
NA.22

Quality Level

200

assay

97%

bp

126-128 °C/6 mmHg (lit.)

mp

30-32 °C (lit.)

SMILES string

ClCc1ccc(cc1)C(Cl)=O

InChI

1S/C8H6Cl2O/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5H2

InChI key

RCOVTJVRTZGSBP-UHFFFAOYSA-N

Related Categories

Application

4-(Chloromethyl)benzoyl chloride was used as an atom transfer radical polymerization (ATRP) initiator in the growth of polyacrylamide (PAAm) brushes from silicon wafers. It was also used as a building block in a microwave-assisted, solid-phase synthesis of imatinib, an anticancer agent.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

target_organs

Respiratory system

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

199.4 °F - closed cup

flash_point_c

93 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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Irina Cringus-Fundeanu et al.
Langmuir : the ACS journal of surfaces and colloids, 23(9), 5120-5126 (2007-03-29)
A method is presented to prevent microbial adhesion to solid surfaces exploiting the unique properties of polymer brushes. Polyacrylamide (PAAm) brushes were grown from silicon wafers by atom transfer radical polymerization (ATRP) using a three-step reaction procedure consisting of immobilization
Tetrahedron Letters, 48, 3455-3455 (2007)
Song Yi Lee et al.
ACS applied materials & interfaces, 10(43), 36628-36640 (2018-10-10)
CD44 receptor targeting and lipid rafts destroying nanoassembly (NA) was developed for breast cancer therapy. Methyl-β-cyclodextrin (MbCD), as a cholesterol depletion moiety, was conjugated to hyaluronic acid-ceramide (HACE) structure via an ester linkage. HACE-MbCD NA with 198 nm hydrodynamic size
Ali Bilgic et al.
Journal of fluorescence, 30(4), 867-881 (2020-06-05)
In this study, we developed two different very sensitive magnetite fluorescent Fe3O4@SiO2-TPED-BODIPY and Fe3O4@SiO2-TMPTA-BODIPY nano-sensors for the selective detection of Cr(VI) ions. The Cr(VI) metal ions sensing is based on the fluorescent quenching of BODIPY functionalized with Fe3O4@SiO2-TPED and Fe3O4@SiO2-TMPTA
Andrej Babič et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(6), 1348-1357 (2017-11-10)
Gadolinium-loaded nanomicelles show promise as future magnetic resonance imaging (MRI) contrast agents (CAs). Their increased size and high gadolinium (Gd) loading gives them an edge in proton relaxivity over smaller molecular Gd-complexes. Their size and stealth properties are fundamental for
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