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270792

Sigma-Aldrich

4-(Chloromethyl)benzoic acid

95%

Synonym(s):

α-Chloro-p-toluic acid, α-Chloro-p-toluylic acid

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About This Item

Empirical Formula (Hill Notation):
C8H7ClO2
CAS Number:
1642-81-5
Molecular Weight:
170.59
Beilstein/REAXYS Number:
1907970
EC Number:
216-697-1
MDL number:
MFCD00002568
UNSPSC Code:
12352100
PubChem Substance ID:
24856400
NACRES:
NA.22

Quality Level

200

assay

95%

form

powder

mp

201-202 °C (lit.)

functional group

carboxylic acid
chloro

SMILES string

OC(=O)c1ccc(CCl)cc1

InChI

1S/C8H7ClO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5H2,(H,10,11)

InChI key

OITNBJHJJGMFBN-UHFFFAOYSA-N

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Application

4-(Chloromethyl)benzoic acid was used in the synthesis of dihydroxy stilbene derivatives.

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

hcodes

H314,H334

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD1848
BCCC0434
BCBS3693V
BCBP8549V
BCBB0068V

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Sheng Yan et al.
Colloids and surfaces. B, Biointerfaces, 188, 110769-110769 (2020-01-10)
Polysulfone (PSf) membrane is widely employed in blood purification fields, but the blood compatibility of PSf membrane is not adequate. To improve the hemocompatibility of PSf membrane, 4-(chloromethyl)benzoic acid (CMBA) and sulfonated hydroxypropyl chitosan (SHPCS) were grafted onto PSf membrane
Marcela Silva Lopes et al.
Anti-cancer agents in medicinal chemistry, 15(2), 206-216 (2014-11-19)
Twenty-seven nitrated and non-nitrated compounds have been synthesized and tested for their growth inhibitory activity on three human cancer cells lines. Fourteen compounds were able to inhibit more than 50% of the growth of at least one of the cancer
Mankil Jung et al.
Bioorganic & medicinal chemistry letters, 17(16), 4481-4486 (2007-06-29)
Dihydroxy stilbene derivatives were designed based on lithospermic acid B and were prepared from 4-(chloromethyl)benzoic acid. The inhibitory activities of the novel compounds against protein tyrosine phosphatase 1B (PTP1B) were evaluated. 3,4-Dihydroxy stilbene carbonyl compounds (7, 11b, 27b) inhibited PTP1B
Yasuo Yoshimi et al.
Analytica chimica acta, 862, 77-85 (2015-02-16)
In this work, the anodic current at an electrode grafted with a molecularly imprinted polymer (MIP) crosslinked via a combination of hydrophobic ethyleneglycol dimethacrylate (EDMA) and hydrophilic methylene bisacrylamide (MBAA) was found to exhibit enantioselective sensitivity to the phenylalanine template

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