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T7572

Sigma-Aldrich

Thrombin from human plasma

400-1000 NIH units/mg protein

Synonim(y):

Factor IIa

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About This Item

Numer CAS:
9002-04-4
Numer EC enzymu:
3.4.21.5 (BRENDA, IUBMB)
Numer WE:
232-648-7
Numer MDL:
MFCD00082072
Kod UNSPSC:
12352204
NACRES:
NA.54

Postać

lyophilized powder

Poziom jakości

200

aktywność właściwa

400-1000 NIH units/mg protein

zanieczyszczenia

HIV, hepatitis B and hepatitis C, tested negative

numer dostępu UniProt

P00734

temp. przechowywania

−20°C

informacje o genach

human ... F2(2147)

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Opis ogólny

Lyophilized powder containing sucrose, sodium chloride and Tris.
Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects.

Zastosowanie

Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess an innovative flow cytometric approach for small-size platelet microparticles.

Działania biochem./fizjol.

Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.

Definicja jednostki

Activity is expressed in NIH units obtained by direct comparison to a NIH Thrombin Reference Standard

Komentarz do analizy

The NIH assay procedure uses 0.2 ml diluted plasma (1:1 with saline) as a substrate and 0.1ml of thrombin sample (stabilized in a 1% buffered albumin solution) based on a modification of the method of Biggs. Only clotting times in the range of 15-25 seconds are used for determining thrombin concentrations.

Inne uwagi

View more information on thrombin at www.sigma-aldrich.com/enzymeexplorer.

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Odwiedź Bibliotekę dokumentów

At the cutting edge: conformational PARtiality.
T Madhusudhan et al.
Journal of thrombosis and haemostasis : JTH, 10(8), 1672-1674 (2012-06-30)
Silvia Montoro-García et al.
Thrombosis and haemostasis, 108(2), 373-383 (2012-06-29)
Microparticles (MPs) are small submicron membrane-derived vesicles shed from a variety of cells and they have been implicated in different disorders. Accordingly, understanding of physiological characteristics of MPs and improvement of methods of their quantification are important for further advance
Walter-Michael Halbmayer et al.
Clinical chemistry and laboratory medicine, 50(9), 1601-1605 (2012-10-27)
Dabigatran etexilate is a new oral anticoagulant for the therapy and prophylaxis of venous thromboembolism and stroke prevention in patients with atrial fibrillation. To investigate the extent of interactions of this new anticoagulant with frequently used coagulation assays, we completed
Herbert Nar
Trends in pharmacological sciences, 33(5), 279-288 (2012-04-17)
The quest for novel medications to treat thromboembolic disorders such as venous thrombosis, pulmonary embolism and stroke received a boost when the 3D structures of two major players in the blood coagulation cascade were determined in 1989 and 1993. Structure-guided
Lukas Graf et al.
Swiss medical weekly, 142, w13684-w13684 (2012-10-06)
New oral anticoagulants used as single target inhibitors of coagulation enzymes have been developed and tested in extensive trial programmes. Results of most of these trials showed non-inferior and/or superior efficacy and safety compared to standard treatment with LMWH or
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Produkty

Trombina Czynnik IIa

Czynnik trombinowy IIa jest endolityczną proteazą serynową, która selektywnie rozszczepia wiązania Arg--Gly fibrynogenu, tworząc fibrynę i uwalniając fibrynopeptydy A i B.

Thrombin Factor IIa

Thrombin Factor IIa is an endolytic serine protease that selectively cleaves the Arg--Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

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