T1815
Monoclonal Anti-Tumor Necrosis Factor Receptor II antibody produced in mouse
clone 22221, purified immunoglobulin, lyophilized powder
Synonim(y):
Anti-TNF RII, Anti-TNFRSF1B
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
22221, monoclonal
Formularz
lyophilized powder
reaktywność gatunkowa
human
metody
immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood lymphocytes
microarray: suitable
neutralization: suitable
izotyp
IgG2a
numer dostępu UniProt
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... TNF(7124)
Opis ogólny
The tumor necrosis factor super family (TNFSF) consists of at least 19 transmembrane proteins with soluble forms that are generated by proteolysis. The biological effects of TNF are mediated by either type I or type II receptors. Type I receptors that are ubiquitously present on all cells whereas type II receptors are expressed only on cells of immune system (monocytes, macrophages, Langerhans cells) and endothelial cells. Receptors of TNFSF such as TNFR I and Fas have their own death domains that activate the apoptosis. Other receptors such as TNFR II do not have death domains and utilize TNF associated factors (TRAFs) to activate intracellular signaling. TNFR II activates NF-κB pathway via the activation of NIK. Monoclonal Anti-Tumor Necrosis Factor Receptor II antibody recognizes human TNFR II.
Specyficzność
The antibody neutralizes the biological effect of recombinant human TNF RII. It does not neutralize or cross-react with TNF RI.
Immunogen
recombinant human tumor necrosis factor receptor II, expressed in Escherichia coli.
Zastosowanie
Anti-Tumor Necrosis Factor Receptor II antibody may be used for immunocytochemistry at a working concentration of 8-25 μg/ml using human peripheral blood lymphocytes. The antibody is suitable for neutralization assays and protein microarray. The antibody was used for flow cytometry using human CD8 T cells.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Uwaga dotycząca przygotowania
Purified using protein A
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Liqin Ban et al.
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Antunes RF et al
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B B Aggarwal
Annals of the rheumatic diseases, 59 Suppl 1, i6-16 (2000-10-29)
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M Lotz et al.
Journal of leukocyte biology, 60(1), 1-7 (1996-07-01)
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