SRP6166
HGF human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonim(y):
F-TCF, HPTA, Hepatocyte growth factor, Hepatopoietin-A (HPTA), Scatter factor (SF)
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About This Item
Kod UNSPSC:
12352202
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in HEK 293 cells
Próba
≥95% (SDS-PAGE)
Formularz
lyophilized
masa cząsteczkowa
70 kDa (single chain, glycosylated)
opakowanie
pkg of 10 μg
metody
cell culture | mammalian: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... HGF(3082)
Opis ogólny
HGF (hepatocyte growth factor) is a multifunctional heterodimeric mitogen, with a relative molecular mass (Mr) of 82,000, consisting of a large α-subunit of Mr 69,000 and a small β -subunit of Mr 34,000. The pre-pro precursor protein is composed of 728 residues. HGF is produced by mesenchymal cells.
The hepatocyte growth factor (HGF) gene is located on human chromosome 7q21.1. It has 18 exons, 17 introns and spans approximately 70 kb. Active HGF is made up of a heavy chain and a light chain, connected covalently with the help of a disulfide bridge.
Działania biochem./fizjol.
HGF (hepatocyte growth factor) functions as a ligand for tyrosine kinase receptor Met. Through interaction with Met receptor, it modulates mitogenesis, motility, and morphogenesis in a cell-specific manner. It is implicated in the growth and scattering of specific cell types, EMT (epithelial mesenchymal transition), formation of lumens and tubules, and angiogenesis. HGF-Met is also involved in neural induction, hepatic regeneration, wound healing, and normal fetal development. In primary culture, HGF acts as a strong mitogen for mature parenchymal hepatocytes, and is thought to be a hepatotrophic factor which induces liver regeneration post-partial hepatectomy and liver injury. In HER2-positive patients with metastatic gastric cancer, the serum level of this protein is linked with the outcome and resistance to trastuzumab therapy.
HGF exhibits mitogenic, motogenic and morphogenic effects in various tissues.
Postać fizyczna
Lyophilized in solution of 10 mM Tris-HCl, pH 7.4, with 1 M NaCl.
Uwaga dotycząca przygotowania
Centrifuge the vial prior to opening.
Rekonstytucja
Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Molecular cloning and expression of human hepatocyte growth factor.
Nakamura T, et al.
Nature, 342(6248), 440-443 (1989)
Serum level of hepatocyte growth factor is a novel marker of predicting the outcome and resistance to the treatment with trastuzumab in HER2-positive patients with metastatic gastric cancer.
Takahashi N, et al.
Oncotarget, 7(4), 925-938 (2016)
Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models.
Cao B, et al.
Proceedings of the National Academy of Sciences of the USA, 98(13) , 7443-7448 (2001)
Rajeswara R Pannem et al.
Hepatology (Baltimore, Md.), 60(3), 1066-1081 (2014-05-09)
Hepatic fibrosis is considered as a physiological wound-healing response to liver injury. The process involves several factors, such as hepatocyte growth factor (HGF), which restrains hepatic injury and facilitates reversibility of fibrotic reaction in response to an acute insult. Chronic
MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma.
Rajani Kanteti et al.
PloS one, 9(9), e105919-e105919 (2014-09-16)
Malignant pleural mesothelioma (MPM) is an aggressive disease with a poor prognosis. Studies have shown that both MET and its key downstream intracellular signaling partners, PI3K and mTOR, are overexpressed in MPM. Here we determined the combinatorial therapeutic efficacy of
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