SRP6158
EPO human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonim(y):
EP, EPO-alpha, Epoetin, Erythropoietin-alpha, MGC138142
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About This Item
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in HEK 293 cells
Próba
≥95% (SDS-PAGE)
Postać
lyophilized
masa cząsteczkowa
36 kDa (monomer, glycosylated)
opakowanie
pkg of 10 μg
metody
cell culture | mammalian: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
human ... EPO(2056)
Powiązane kategorie
Opis ogólny
The gene EPO (erythropoietin) is mapped to human chromosome 7q22. It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs. EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.
Zastosowanie
- EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.
- In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.
- It has also been used as a component of endothelial differentiation medium.
Działania biochem./fizjol.
EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.
Postać fizyczna
Lyophilized from a PBS solution.
Uwaga dotycząca przygotowania
Centrifuge the vial prior to opening.
Rekonstytucja
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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To evaluate erythropoietin (Epo) and erythropoietin receptor (EpoR) expression, its relationship with vasculogenic mimicry (VM) and its prognostic value in human hepatocellular carcinoma (HCC), we examined Epo/EpoR expression and VM formation using immunohistochemistry and CD31/PAS (periodic acid-Schiff) double staining on
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