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Kluczowe dokumenty
M6908
Myeloperoxidase from human leukocytes
lyophilized powder, ≥50 units/mg protein
Synonim(y):
MPO, Peroxidase, myelo
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About This Item
Numer CAS:
Numer MDL:
Kod UNSPSC:
12352200
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human leucocytes
Poziom jakości
Formularz
lyophilized powder
aktywność właściwa
≥50 units/mg protein
rozpuszczalność
H2O: soluble
aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
ciąg SMILES
[O+H2]O[O-]
InChI
1S/H2O3/c1-3-2/h1-2H
Klucz InChI
JSPLKZUTYZBBKA-UHFFFAOYSA-N
informacje o genach
human ... MPO(4353)
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Opis ogólny
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.
Zastosowanie
Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO
Działania biochem./fizjol.
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).
Inne uwagi
Lysosomal heme-containing protein.
Definicja jednostki
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C
Postać fizyczna
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Komentarz do analizy
Source material tested and found negative for antibody to HIV and for HBSAG.
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Inhibitor
Numer produktu
Opis
Cennik
substrat
Numer produktu
Opis
Cennik
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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