Przejdź do zawartości
Merck

SML1842

Sigma-Aldrich

Ibuprofen Arginate

≥98% (HPLC)

Synonim(y):

α-Methyl-4-(2-methylpropyl)benzeneacetate, L-arginine (1:1), (S)-1-(4-Amino-4-carboxybutyl)guanidinium 2-(4-isobutylphenyl)propanoate, Ibu-L-Arg, Ibuprofen L-arginine, Ibuprofen arginine

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych


About This Item

Wzór empiryczny (zapis Hilla):
C19H32N4O4
Numer CAS:
Masa cząsteczkowa:
380.48
Kod UNSPSC:
51111800
NACRES:
NA.77

Poziom jakości

Próba

≥98% (HPLC)

Postać

powder

kolor

white to beige

rozpuszczalność

H2O: 20 mg/mL, clear

temp. przechowywania

−20°C

ciąg SMILES

CC(CC1=CC=C(C(C([O-])=O)C)C=C1)C.O=C(O)[C@@H](N)CCCNC([NH3+])=N

InChI

1S/C13H18O2.C6H14N4O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15;7-4(5(11)12)2-1-3-10-6(8)9/h4-7,9-10H,8H2,1-3H3,(H,14,15);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t;4-/m.0/s1

Klucz InChI

GCCOJNYCFNSJII-VWMHFEHESA-N

Działania biochem./fizjol.

Ibuprofen arginate is the more soluble arginate salt form of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen. Ibuprofen arginate retains the inhibitory potency against COX-2 as ibuprofen and its sodium salt, however only ibuprofen arginate is able to augment cellular NO pathway through codelivery of the NOS substrate arginine. Ibuprofen arginate, but not the sodium salt form, is shown to reverse the inhibitory effects of the cardiotoxic hormone asymmetric dimethylarginine (ADMA) and NG-nitro-L-argininemethyl ester (L-NAME) against nitric oxide synthase (eNOS & iNOS) in cultures in vitro (Murine RAW264.7 macrophages and isolated mouse & rat aorta) and effectively prevent L-NAME-induced arterial blood pressure increase in anesthetized rats in vivo (0.5 mg/kg L-NAME; 114.8 μmol/kg ibuprofen arginate, equivalent to 20 mg/kg L-Arg via femoral artery cannulation).
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Lobna A Saleh et al.
Pharmacology, biochemistry, and behavior, 125, 29-39 (2014-08-08)
Prostaglandins (PGs) and nitric oxide (NO) may be involved in the pathophysiology of depression. Since NSAIDs decrease PGs and NO production, they may have an antidepressant effect. The aim of the present work was to explore a possible antidepressant action
Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing.
Ahmetaj-Shala, B., et al.
Biochemical and Biophysical Research Communications, 18484(4), 762-766 (2017)
Ghada M El-Lithy et al.
Translational research : the journal of laboratory and clinical medicine, 177, 85-97 (2016-07-10)
Diabetic neuropathy (DN) is a common complication of diabetes mellitus that is hardly reversible at the late stages. Since treatment of neuropathic pain is predominantly symptomatic, a prophylactic measure would be useful. Both ibuprofen and L-arginine exert antiallodynic effects on
Nicholas S Kirkby et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(12), 4172-4179 (2016-09-08)
Nonsteroidal antiinflammatory drugs, including ibuprofen, are among the most commonly used medications and produce their antiinflammatory effects by blocking cyclooxygenase (COX)-2. Their use is associated with increased risk of heart attacks caused by blocking COX-2 in the vasculature and/or kidney

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej