R5010

Resveratrol

≥99% (HPLC)

• Synonim(y): 3,4′,5-Trihydroxy-trans-stilbene, 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
• Wzór empiryczny (zapis Hilla): C₁₄H₁₂O₃
• Numer CAS: 501-36-0
• Masa cząsteczkowa: 228.24
• Numer MDL: MFCD00133799
• Kod UNSPSC: 12352205
• Identyfikator substancji w PubChem: 24278055
• NACRES: NA.25

Właściwości

• pochodzenie biologiczne: plant root (bushy knotweed)
• Próba: ≥99% (HPLC)
• Postać: powder
• rozpuszczalność: acetone: 50 mg/mL, clear, faintly yellow
• Zastosowanie: metabolomics; vitamins, nutraceuticals, and natural products
• temp. przechowywania: −20°C
• ciąg SMILES: Oc1ccc(cc1)\C=C\c2cc(O)cc(O)c2
• InChI: 1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
• Klucz InChI: LUKBXSAWLPMMSZ-OWOJBTEDSA-N
• informacje o genach: human ... AR(367) , CYP1A2(1544) , ESR1(2099) , SIRT1(23411) ; mouse ... Nos2(18126) ; rat ... Esr1(24890)

Opis

Zastosowanie

Resveratrol has been used:

• in entrapment experiment
• to study its neuroprotective effect on retinal neuronal cell death mediated by diabetes-induced activation of Ca²⁺/calmodulin-dependent protein kinase II
• as a standard in the assessment of stilbene content in grapevine leaf by in vivo fluorometry

Selective inhibitor of COX−1.

Działania biochem./fizjol.

Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD⁺)-dependent histone deacetylase involved in mitochondrial biogenesis and the enhancement of peroxisome proliferator-g-activated receptor coactivator-1a (PGC-1a) and FOXO (forkhead box) activity. The anti-diabetic, neuroprotective and anti-adipogenic actions of resveratrol may be mediated via SIRT1 activation. Resveratrol has antiviral action against Herpes simplex virus-1 (HSV1) and HSV2. It also exhibits antitumor and phytoestrogenic biological activities. Resveratrol is known to prolong life in many species by mediating several physiological events.

Uwaga dotycząca przygotowania

Soluble in ethanol, DMSO, and acetone. Only very slightly soluble in water (3 mg/100 mL).

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H319
• Zwroty wskazujące środki ostrożności: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Klasyfikacja zagrożeń: Eye Irrit. 2
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): >392.0 °F - closed cup - (External MSDS)
• Temperatura zapłonu (°C): > 200.0 °C - closed cup - (External MSDS)
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves