SML1518

SID 3712249

≥95% (HPLC)

• Synonim(y): 1,8-Diamino-3,6-di-1-pyrrolidinyl-2,7-naphthyridine-4-carbonitrile, MLS000054131, MiR-544 Inhibitor 1
• Wzór empiryczny (zapis Hilla): C₁₇H₂₁N₇
• Numer CAS: 522606-67-3
• Masa cząsteczkowa: 323.40
• Numer MDL: MFCD03483890
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329825935
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: powder
• warunki przechowywania: protect from light
• kolor: white to brown
• rozpuszczalność: DMSO: 15 mg/mL, clear
• temp. przechowywania: room temp
• ciąg SMILES: NC1=C2C(C=C(N3CCCC3)N=C2N)=C(C#N)C(N4CCCC4)=N1
• InChI: 1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22)
• Klucz InChI: SSWVPYMSHHEYAB-UHFFFAOYSA-N

Opis

Działania biochem./fizjol.

SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.

Inne uwagi

light sensitive

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable