SML1350

EPPTB

≥95% (HPLC)

• Synonim(y): N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide, RO5212773
• Wzór empiryczny (zapis Hilla): C₂₀H₂₁F₃N₂O₂
• Numer CAS: 1110781-88-8
• Masa cząsteczkowa: 378.39
• Numer MDL: MFCD21605509
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329825806
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: powder
• kolor: white to beige
• rozpuszczalność: DMSO: 20 mg/mL, clear
• temp. przechowywania: 2-8°C
• ciąg SMILES: CCOC1=CC=CC(NC(C2=CC(C(F)(F)F)=C(N3CCCC3)C=C2)=O)=C1
• InChI: 1S/C20H21F3N2O2/c1-2-27-16-7-5-6-15(13-16)24-19(26)14-8-9-18(25-10-3-4-11-25)17(12-14)20(21,22)23/h5-9,12-13H,2-4,10-11H2,1H3,(H,24,26)
• Klucz InChI: KLFVWQCQUXXLOU-UHFFFAOYSA-N

Opis

Działania biochem./fizjol.

EPPTB is a selective antagonist of the trace amine-associated receptor 1 (TAAR1), a G protein-coupled receptor (GPCR) activated by endogenous trace amines (tyramine, tryptamine, synephrine, octopamine, β)-phenylethylamine), which are chemically similar to monoaminergic neurotransmitters (epinephrine, norepinephrine, dopamine). TAAR1 is considered a promising target for the treatment of neuropsychiatric disorders, however study of TAAR1 has hampered by the fact that selective ligands have not been available. EPPTB is the first potent and selective TAAR1 antagonist with an IC₅₀ of 28 nM at mouse TAAR1. EPPTB is less selective for rat and human with IC₅₀ values of 4539 and 7487 nM, respectively.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable