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L9908

Sigma-Aldrich

LY-294,002 hydrochloride

from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor

Synonim(y):

2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride

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About This Item

Wzór empiryczny (zapis Hilla):
C19H17NO3 · HCl
Numer CAS:
934389-88-5
Masa cząsteczkowa:
343.80
Numer MDL:
MFCD00270881
Kod UNSPSC:
12352207
Identyfikator substancji w PubChem:
24278828
NACRES:
NA.77

product name

LY-294,002 hydrochloride, solid, ≥98% (HPLC)

pochodzenie biologiczne

microbial (Staphylococcus roseus)

Poziom jakości

100

Próba

≥98% (HPLC)

Postać

solid

kolor

white to off-white

rozpuszczalność

DMSO: >5 mg/mL
H2O: insoluble

temp. przechowywania

2-8°C

ciąg SMILES

O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4

InChI

1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2

Klucz InChI

CZQHHVNHHHRRDU-UHFFFAOYSA-N

Opis ogólny

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Zastosowanie

LY-294,002 hydrochloride has been used in the inhibition of:
  • phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
  • autophagy in mesenchymal stem cells (MSCs).
  • serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

Działania biochem./fizjol.

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Cechy i korzyści

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Carboxyl-Terminal Modulator Protein Ameliorates Pathological Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling Pathway
Liu X, et al.
Journal of the American Heart Association, 7(13), e008654-e008654 (2018)
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
Walker EH, et al.
Molecular Cell, 6(4), 909-919 (2000)
Regulation of PKCbeta levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis
Morganti C, et al.
International Journal of Obesity, 1-1 (2018)
C J Vlahos et al.
Journal of immunology (Baltimore, Md. : 1950), 154(5), 2413-2422 (1995-03-01)
Neutrophils contain a multicomponent NADPH oxidase system that is involved in the production of microbicidal oxidants. Stimulation of human neutrophils with the peptide FMLP activates this respiratory burst enzyme to produce superoxide and also has been shown to result in
G J Brunn et al.
The EMBO journal, 15(19), 5256-5267 (1996-10-01)
The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a novel kinase, termed mammalian target of rapamycin (mTOR). The putative catalytic domain of mTOR is similar to those of mammalian and yeast phosphatidylinositol (PI) 3-kinases. This study
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Produkty

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