SML0943
YM-1
Synonim(y):
2-[[3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-1-methyl-pyridinium chloride
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About This Item
Wzór empiryczny (zapis Hilla):
C20H20ClN3OS2
Numer CAS:
Masa cząsteczkowa:
417.98
Kod UNSPSC:
12352200
NACRES:
NA.77
Polecane produkty
Próba
≥98% (HPLC)
Poziom jakości
Formularz
powder
kolor
orange to dark red
rozpuszczalność
H2O: 2 mg/mL, clear (warmed)
temp. przechowywania
2-8°C
Zastosowanie
YM-1 has been used as a Hsp70 (heat shock protein) inhibitor in cell viability assay.
Działania biochem./fizjol.
YM-1 is a Hsp70 modulator; anticancer agent.
YM-1 modulates Hsp70 activity by binding to the nucleotide-binding domain of ADP- but not ATP-bound Hsp70, stabilizing Hsp70 in its ADP-bound conformation. The ADP-bound state has tight affinity for its substrates, promoting their ubiquitination and degradation, and a greatly reduced off rate compared to the ATP-bound state. YM-1 appears to behave in a similar manner to Hip, a Hsp70 co-chaperone that stabilizes Hsp70 in its ADP-bound conformation which favors degradation of misfolded substrates such as those involved in various neurodegenerative diseases.
YM-1 also has anticancer activity, which could be due to enhanced ubiquitination and clearance of Akt, a major survival kinase. In studies with multiple cancer lines, YM-1 was found to selectively target cancer cells over normal cells and to overcome tamoxifen resistance in a tamoxifen-resistant MCF7 cell model. YM-1 had greater efficacy and cytosolic localization than the closely related MKT-077 (M5449).
YM-1 also has anticancer activity, which could be due to enhanced ubiquitination and clearance of Akt, a major survival kinase. In studies with multiple cancer lines, YM-1 was found to selectively target cancer cells over normal cells and to overcome tamoxifen resistance in a tamoxifen-resistant MCF7 cell model. YM-1 had greater efficacy and cytosolic localization than the closely related MKT-077 (M5449).
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Effect of an Inhibitor of HSP70, YM-1, on Hikeshi Knockout Cells.
RAHMAN K Z, et al.
Japanese Society for Thermal Medicine, 33(4), 117-122 (2017)
Chieh-Ting Fang et al.
Cell death & disease, 11(8), 715-715 (2020-09-03)
The heat shock protein 70 (HSP70) is a conserved molecular chaperone and proteostasis regulator that protects cells from pharmacological stress and promotes drug resistance in cancer cells. In this study, we found that HSP70 may promote resistance to anticancer drugs
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