SML0420

TAPI-2 acetate salt

≥98% (HPLC)

• Synonim(y): N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide, Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2
• Wzór empiryczny (zapis Hilla): C₁₉H₃₇N₅O₅ · xC₂H₄O₂
• Numer CAS: 689284-12-6
• Masa cząsteczkowa: 415.53 (free base basis)
• Numer MDL: MFCD22666396
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329825415
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: lyophilized powder
• kolor: white to off-white
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• ciąg SMILES: CC(O)=O.CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C
• InChI: 1S/C19H37N5O5.C2H4O2/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20;1-2(3)4/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25);1H3,(H,3,4)/t12-,13+,15+;/m0./s1
• Klucz InChI: LMUSZKBIFGOFBD-RAFLFFCLSA-N

Opis

Zastosowanie

TAPI-2 acetate salt has been used to inhibit protease activity in HepG2 cells.

Działania biochem./fizjol.

TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase).

TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). It blocks the shedding of several cell surface proteins such as β-amyloid precursor protein, inhibits TNF-α release as well as a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands. TAPI-2 is considered a fairly broad metalloproteinase inhibitor, but it much more selective for TACE than GM6001.

Cechy i korzyści

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable