SML0063

Q-VD-OPh hydrate

≥95% (HPLC), powder, pan-caspase inhibitor

• Synonim(y): 5-(2,6-Difluorophenoxy)-3-[[3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate
• Wzór empiryczny (zapis Hilla): C₂₆H₂₅F₂N₃O₆ · xH₂O
• Numer CAS: 1435786-01-8
• Masa cząsteczkowa: 513.49 (anhydrous basis)
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329825128
• NACRES: NA.77

Właściwości

• Nazwa produktu: Q-VD-OPh hydrate, ≥95% (HPLC)
• Próba: ≥95% (HPLC)
• Formularz: powder
• warunki przechowywania: desiccated
• kolor: white to light brown
• rozpuszczalność: DMSO: ≥14 mg/mL
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• ciąg SMILES: O=C(NC(C(C)C)C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(O)=O)=O)C2=NC3=CC=CC=C3C=C2.[H]O[H]
• InChI: 1S/C26H25F2N3O6.H2O/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28;/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34);1H2/t20-,23-;/m0./s1
• Klucz InChI: ONOTWLLTFZMERH-WCRWPNQISA-N

Opis

Zastosowanie

Q-VD-OPh hydrate has been used:

• as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
• to induce canonical caspase-dependent apoptosis in UC cells
• to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
• to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells

Działania biochem./fizjol.

Pan-caspase inhibitor.

Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.

Cechy i korzyści

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable