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Key Documents

Inne dokumenty

C2105

Sigma-Aldrich

Z-Val-Ala-Asp fluoromethyl ketone

powder, ≥90% (TLC)

Synonim(y):

Z-VAD-FMK, Non-methylated

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About This Item

Wzór empiryczny (zapis Hilla):
C21H28FN3O7
Numer CAS:
161401-82-7
Masa cząsteczkowa:
453.46
Numer MDL:
MFCD03452883
Kod UNSPSC:
12352209
Identyfikator substancji w PubChem:
329774926
NACRES:
NA.77

Poziom jakości

200

Próba

≥90% (TLC)

Postać

powder

Warunki transportu

dry ice

temp. przechowywania

−20°C

ciąg SMILES

CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CF

InChI

1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1

Klucz InChI

SUUHZYLYARUNIA-YEWWUXTCSA-N

Amino Acid Sequence

Z-Val-Ala-Asp-OMe-FMK

Działania biochem./fizjol.

Non-methylated competitive and irreversible inhibitor of caspase-1, as well as other caspases, which can be used directly with purified enzymes. It does not require esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(OMe) fluoromethyl ketone (Product Code V-116).

Cechy i korzyści

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Teruyuki Kajiume et al.
Cell death discovery, 4, 111-111 (2018-12-12)
Mature neutrophils must be quickly removed from inflammatory sites to prevent tissue damage. Neutrophil removal is thought to be accomplished primarily through caspase-dependent apoptosis, which involves several genes of mitochondrial origin. However, mature neutrophils show reduced gene transcription and mitochondrial
Tonghui Li et al.
Frontiers in pharmacology, 13, 854526-854526 (2022-06-07)
Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), derived from some Chinese edible medicinal herbs, exerts a potential anticancer activity on various cancer cells, making it a drug candidate for cancer therapy. Yet, the role of aloe-emodin in pyroptosis, a new type of cell death, is
Feng Shi et al.
Theranostics, 9(9), 2424-2438 (2019-05-28)
EBV infection is a recognized epigenetic driver of carcinogenesis. We previously showed that EBV could protect cancer cells from TNF-induced necroptosis. This study aims to explore the epigenetic mechanisms allowing cancer cells with EBV infection to escape from RIP3-dependent necroptosis.
Shuiping Liu et al.
Signal transduction and targeted therapy, 4, 53-53 (2019-12-10)
5-Fluorouracil (5-FU) is known as a first-line chemotherapeutic agent against colorectal cancer (CRC), but drug resistance occurs frequently and significantly limits its clinical success. Our previous study showed that the protocadherin 17 (PCDH17) gene was frequently methylated and functioned as
Hyojung Kim et al.
Brain : a journal of neurology, 144(12), 3674-3691 (2021-09-29)
Aberrant activation of the non-receptor kinase c-Abl is implicated in the development of pathogenic hallmarks of Parkinson's disease, such as α-synuclein aggregation and progressive neuronal loss. c-Abl-mediated phosphorylation and inhibition of parkin ligase function lead to accumulation of parkin interacting

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