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Kluczowe dokumenty
SBR00017
Puromycin aminonucleoside Ready Made Solution
10 mg/mL in water
Synonim(y):
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
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About This Item
Wzór empiryczny (zapis Hilla):
C12H18N6O3
Numer CAS:
Masa cząsteczkowa:
294.31
Kod UNSPSC:
51281912
NACRES:
NA.85
Polecane produkty
Próba
≥98%
Poziom jakości
Postać
liquid
stężenie
10 mg/mL in water
spektrum działania antybiotyku
Gram-positive bacteria
neoplastics
parasites
Tryb działania
protein synthesis | interferes
temp. przechowywania
2-8°C
ciąg SMILES
N[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C)C)=NC=N3)O[C@@H]1CO
InChI
1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3
Klucz InChI
RYSMHWILUNYBFW-UHFFFAOYSA-N
Działania biochem./fizjol.
Puromycin aminonucleoside is an aminonucleoside derivative of the known antibiotic puromycin. Puromycin aminonucleoside has been used in nephrology research, studying focal and segmental glomerulosclerosis, and in the induction of nephrosis in rats. Rats with puromycin aminonucleoside-induced nephrotic syndrome were used to study the excretion of sodium and NOx metabolites.
Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).
Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).
Uwaga dotycząca przygotowania
Puromycin aminonucleoside solution is provided at 10 mg/mL in water and could be further diluted in aqueous buffers to a working concentration of 10 μg/mL (1:1000).
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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