P7130

Puromycin aminonucleoside

• Synonim(y): 3′-Amino-3′-deoxy-N⁶,N⁶-dimethyladenosine
• Wzór empiryczny (zapis Hilla): C₁₂H₁₈N₆O₃
• Numer CAS: 58-60-6
• Masa cząsteczkowa: 294.31
• Beilstein: 93902
• Numer WE: 200-388-3
• Numer MDL: MFCD00063462
• Kod UNSPSC: 51281912
• Identyfikator substancji w PubChem: 24898823
• NACRES: NA.85

Właściwości

• Postać: powder
• Poziom jakości: 300
• rozpuszczalność: H₂O: soluble 50 mg/mL
• spektrum działania antybiotyku: Gram-positive bacteria; neoplastics; parasites
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: 2-8°C
• ciąg SMILES: CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O
• InChI: 1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1
• Klucz InChI: RYSMHWILUNYBFW-VENHTOENSA-N

Opis

Opis ogólny

Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin. It is useful in nephrology research, like studies of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and nitrite (NOx) metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome are studied. Puromycin aminonucleoside-induced nephrosis in rats has been studied with respect to the production of reactive oxygen species during the acute phase. Puromycin aminonucleoside is used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.

Zastosowanie

Puromycin aminonucleoside has been used:

• as a selection marker for the infected cells for the transfection of lentivirus
• as a component of fresh medium for transfection and infection assays
• to subcutaneously induce puromycin aminonucleoside nephrosis to investigate the mRNA and protein levels of nephrin and podocin before the onset of proteinuria

Działania biochem./fizjol.

Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes and is used to study glomerular function and morphology.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H373
• Klasyfikacja zagrożeń: STOT RE 2
• Organy docelowe: Kidney
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)