SAB5300461

Monoclonal Anti-FOXP3 antibody produced in mouse

clone 2A11G9, ascites fluid

• Synonim(y): AIID, IPEX, JM2, PIDX, XPID
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• białko sprzężone: unconjugated
• forma przeciwciała: ascites fluid
• rodzaj przeciwciała: primary antibodies
• klon: 2A11G9, monoclonal
• reaktywność gatunkowa: mouse, human
• metody: direct ELISA: 1:10,000; immunohistochemistry: 1:200-1:1,000; indirect immunofluorescence: 1:200-1:1,000; western blot: 1:500-1:2,000
• izotyp: IgG1
• numer dostępu NCBI: NM_014009
• numer dostępu UniProt: Q9BZS1
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... Foxp3(50943)

Opis

Opis ogólny

Forkhead box P3 (FOXP3) is located on human chromosome Xp11.23-Xq13.3. FOXP3 is a putative DNA-binding protein and is a member of the forkhead family. The protein is mainly expressed in the CD4⁺CD25⁺ regulatory T-cell subsets.

Immunogen

Purified recombinant fragment of human Foxp3 expressed in E.coli.
Mouse monoclonal antibody raised against Foxp3

Zastosowanie

Monoclonal Anti-FOXP3 antibody has been used in immunohistochemistry (IHC).

Działania biochem./fizjol.

Forkhead box P3 (FOXP3) plays an essential role in the development of CD4⁺CD25⁺ regulatory T cells and regulates immune homeostasis. It also acts as a transcriptional repressor. Polyadenylation signal mutation of the gene leads to immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (IPEX). Abnormalities in the gene expression are also associated with the pathogenesis of autism spectrum disorders (ASD) and unexplained recurrent spontaneous abortion (URSA).

Postać fizyczna

Ascitic fluid containing 0.03% sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable