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SAB4300456

Sigma-Aldrich

Anti-EFNB2 (Ab-330) antibody produced in rabbit

affinity isolated antibody

Synonim(y):

Anti-EPLG5 antibody produced in rabbit, Anti-HTKL antibody produced in rabbit, Anti-Htk-L antibody produced in rabbit, Anti-LERK5 antibody produced in rabbit, Anti-ephrin-B2 antibody produced in rabbit

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

100

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

masa cząsteczkowa

~37 kDa

reaktywność gatunkowa

rat, mouse, human

stężenie

1 mg/mL

metody

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

izotyp

IgG

sekwencja immunogenna

(N-I-Y-Y-K)

numer dostępu NCBI

NP_004084.1

numer dostępu UniProt

P52799

Warunki transportu

wet ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... EFNB2(1948)

Opis ogólny

EFNB2 (ephrin B2) is a membrane-bound molecule , that is located on human chromosome 13q33.

Immunogen

Peptide sequence around aa. 328-332 (N-I-Y-Y-K), according to the protein EFNB2.

Działania biochem./fizjol.

EFNB2 (ephrin B2) regulates the development of arterial endothelial cell. It also modulates the movement and adherence of vascular smooth muscle cells and pericytes to the extending arterial endothelial cell tubes. Overexpression of EFNB2 results in low tumor stage and elevated expression of TrkA in neuroblastomas. It controls the growth of thymocyte and differentiation of peripheral T cell. It is required for interleukin-6 (IL-6) signaling. It also modulates the antiviral immune responses.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Opis wartości docelowych

Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.

Postać fizyczna

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas
Tang XX, et al.
Clinical Cancer Research, 5(6), 1491-1496 (1999)
Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling
Luo H, et al.
The Journal of Biological Chemistry, 286(48), 41135-41152 (2011)
Jaeho Yoon et al.
Nature communications, 9(1), 3491-3491 (2018-08-30)
Although Eph-ephrin signalling has been implicated in the migration of cranial neural crest (CNC) cells, it is still unclear how ephrinB transduces signals regulating this event. We provide evidence that TBC1d24, a putative Rab35-GTPase activating protein (Rab35 GAP), complexes with
Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease
Hicks PJ, et al.
American Journal of Nephrology, 28(6), 914-920 (2008)
Fengqing Hu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(7), 7225-7232 (2014-04-29)
Eph/ephrin signaling system plays a very important role in the tumorigenesis and the formation of blood vessel. However, the function of EphB4 and its ligand ephrin B2 in the carcinogenesis of esophageal squamous cell carcinoma (ESCC) is not fully understood.

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