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Merck

SAB4200097

Sigma-Aldrich

Anti-NOX1 antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

Synonim(y):

Anti-GP91-2, Anti-MOX1 (mitogenic oxidase 1), Anti-NADPH oxidase 1, Anti-NOH1 (NADPH oxidase homolog 1)

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

rabbit

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

masa cząsteczkowa

antigen ~72 kDa

reaktywność gatunkowa

human

stężenie

~1.5 mg/mL

metody

immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded human colon
western blot: 0.5-1.0 μg/mL using HS68 cell extracts

numer dostępu UniProt

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... NOX1(27035)
mouse ... Nox1(237038)
rat ... Nox1(114243)

Opis ogólny

NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.

Zastosowanie

Anti-NOX1 antibody produced in rabbit has been used in:
  • Immunocytochemistry.
  • Immunoprecipitation
  • Immunoblotting.
Anti-NOX1 antibody produced in rabbit may be used in immunofluorescence and immunohistochemistry.

Działania biochem./fizjol.

NADPH oxidase 1 (NOX1) requires two cytosolic regulators NADPH oxidase activator 1(NOXA1) and NADPH oxidase organizer 1 (NOXO1) as well as Ras-related C3 botulinum toxin substrate 1 (Rac1) for its activity. NOX1 and NOX2 promote neurotoxic activation of microglia suggesting that they play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS). In ALS mice deletion of either NOX1 and NOX2 gene have been shown to significantly slowed disease progression and improved survival.
NOX1 catalyzes the production of hydrogen peroxide (H2O2). Overexpression of the protein leads to the production of both superoxide and H2O2 and triggers angiogenic switch, mediating vascularization and rapid expansion of the tumor. Elevated expression of NOX1 has been observed in the brain of Parkinson′s disease (PD) patients.

Postać fizyczna

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury.
Fischer MT
Brain, 135, 886-899 (2012)
Reactive oxygen generated by Nox1 triggers the angiogenic switch
Arbiser JL
Proceedings of the National Academy of Sciences of the USA, 99, 715-720 (2002)
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells.
Hilenski LL
Archives of Virology. Supplementum, 24, 677-683 (2004)
NADPH oxidases in Parkinson's disease: a systematic review.
Belarbi K
Mol. Neurodegener., 12 (2017)
Anthony J Valente et al.
Cellular signalling, 25(6), 1447-1456 (2013-04-02)
We investigated the role of TRAF3 interacting protein 2 (TRAF3IP2), a redox-sensitive adapter protein and an upstream regulator of IKK and JNK in interleukin (IL)-18 induced smooth muscle cell migration, and the mechanism of its inhibition by simvastatin. The pleiotropic

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