SAB2500409

Anti-FOXA2/HNF3B antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonim(y): Anti-Forkhead box A2, Anti-HNF3B, Anti-Hepatic nuclear factor-3-β, Anti-MGC19807, Anti-TCF3B
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: goat
• Poziom jakości: 100
• białko sprzężone: unconjugated
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• Formularz: buffered aqueous solution
• reaktywność gatunkowa: human, mouse, rat
• metody: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• numer dostępu UniProt: Q9Y261
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• informacje o genach: human ... FOXA2(3170)

Opis

Opis ogólny

Forkhead box A2 (FOXA2), also known as hepatocyte nuclear factor 3-β (HNF3-β), is encoded by the gene mapped to human chromosome 20p11.21. It is expressed in the liver, pancreas, intestine, and lungs. FOXA2 is a member of forkhead box (FOX) gene family and is characterized by a DNA binding “winged helix domain”.

Immunogen

Peptide with sequence C-GVYSRPIMNSS from the C Terminus of the protein sequence according to NP_068556.1; NP_710141.1.

Działania biochem./fizjol.

Forkhead box A2 (FOXA2) or HNF3β is associated with embryonic formation of the primitive streak and endoderm. It also plays an important role in airway epithelial differentiation and is extensively expressed in type II pneumocytes. Decreased expression of FOXA2 is observed in lung cancer and non-small-cell lung cancer (NSCLC). FOXA2 plays a vital role in normal pancreatic β-cell function and aberration in the expression of the gene leads to hyperinsulinemic hypoglycemia. It also has an essential role in pancreatic α-cell differentiation. FOXA2 acts a regulator of the network of genes associated with intestinal epithelial cell function. Increased expression of FOXA2 in MKN-45 cells (human gastric cancer cell line) elevates E-cadherin expression and inhibits gastric cancer cell migration and invasion and therefore, FOXA2 is expressed at low levels in gastric adenocarcinoma tissues.

Cechy i korzyści

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Postać fizyczna

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H315,H319
• Zwroty wskazujące środki ostrożności: P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Skin Irrit. 2
• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable