S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• Synonim(y): 1-Isothiocyanato-4-(methylsulfinyl)-butane
• Wzór empiryczny (zapis Hilla): C₆H₁₁NOS₂
• Numer CAS: 4478-93-7
• Masa cząsteczkowa: 177.29
• Numer MDL: MFCD00198068
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24724610
• NACRES: NA.77

Właściwości

• product name: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• pochodzenie biologiczne: synthetic
• Poziom jakości: 200
• Próba: ≥90% (HPLC)
• Postać: liquid
• rozpuszczalność: DMSO: soluble 40 mg/mL; H₂O: insoluble
• kompatybilność: for use with ABI 7500
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
• Klucz InChI: SUVMJBTUFCVSAD-UHFFFAOYSA-N

Opis

Zastosowanie

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Działania biochem./fizjol.

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)