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Key Documents
RAB0711
Human CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit
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About This Item
Kod UNSPSC:
41116158
NACRES:
NA.84
Polecane produkty
reaktywność gatunkowa
human
opakowanie
kit of 96 wells (12 strips x 8 wells)
metody
ELISA: suitable
assay range
inter-assay cv: <10%
intra-assay cv: <12%
metoda wykrywania
colorimetric
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... CSF1R(1436)
Powiązane kategorie
Opis ogólny
CSF1R (colony stimulating factor 1 receptor) is a member of the platelet-derived growth factor (PDGF) family of proteins and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.
The antibody pair provided in this kit recognizes human Macrophage Colony-stimulating Factor 1 Receptor.
Zastosowanie
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Działania biochem./fizjol.
CSF1R (colony stimulating factor 1 receptor) acts as a receptor for CSF1 and regulates monocyte and macrophage functioning. The protein and its ligand are linked to poor prognosis in patients with solid tumors and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Met. Corr. 1
Kod klasy składowania
8A - Combustible corrosive hazardous materials
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS.
Konno T, et al.
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Audrey C Knight et al.
Journal of neuropathology and experimental neurology, 77(3), 199-206 (2018-01-11)
Chronic microglial activation and associated neuroinflammation are key factors in neurodegenerative diseases including HIV-associated neurocognitive disorders. Colony stimulating factor 1 receptor (CSF1R)-mediated signaling is constitutive in cells of the myeloid lineage, including microglia, promoting cell survival, proliferation, and differentiation. In
A Patsialou et al.
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