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Merck

P7136

Sigma-Aldrich

Pyrazinecarboxamide

Synonim(y):

Pyrazinamide, Pyrazinoic acid amide

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About This Item

Wzór empiryczny (zapis Hilla):
C5H5N3O
Numer CAS:
Masa cząsteczkowa:
123.11
Beilstein:
112306
Numer WE:
Numer MDL:
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
NACRES:
NA.85

Postać

powder

mp

189-191 °C (lit.)

spektrum działania antybiotyku

mycobacteria

Tryb działania

cell membrane | interferes

ciąg SMILES

NC(=O)c1cnccn1

InChI

1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)

Klucz InChI

IPEHBUMCGVEMRF-UHFFFAOYSA-N

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Zastosowanie

Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .

Działania biochem./fizjol.

The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide . Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


Certyfikaty analizy (CoA)

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