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P2871

Sigma-Aldrich

Anti-Cytokeratin pan antibody, Mouse monoclonal

clone C-11, purified from hybridoma cell culture

Synonim(y):

Anti-CK-4, Anti-CK4, Anti-CYK4, Anti-K4, Anti-WSN1

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

mouse

białko sprzężone

unconjugated

forma przeciwciała

purified from hybridoma cell culture

rodzaj przeciwciała

primary antibodies

klon

C-11, monoclonal

Postać

buffered aqueous solution

metody

immunocytochemistry: 15-30 μg/mL using methanol/acetone-fixed PTK-2 cells or A549 - human lung carcinoma cells
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15-30 μg/mL using human skin
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: suitable

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

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Opis ogólny

Monoclonal Anti-Cytokeratin, pan (mouse IgG1 isotype) is derived from the C-11 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a keratin-enriched preparation from cultured human epidermoid carcinoma cell line A431. Cytokeratin is a member of the intermediate filaments family.

Zastosowanie

Monoclonal Anti-Cytokeratin pan antibody has been used in immunoblotting, dot blot, immunohistochemistry, immunocytochemistry, immunofluorescence, immunostaining, detecting micro-metastases in lymph nodes, bone marrow, and other tissues and for determining the origin of poorly differentiated tumors.

Działania biochem./fizjol.

Cytokeratin plays a major role in observing carcinomas.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Gloria Valdés et al.
Reproductive sciences (Thousand Oaks, Calif.), 27(8), 1648-1655 (2020-05-21)
The pleiotropic kininogen-kallikrein-kinin system is upregulated in pregnancy and localizes in the uteroplacental unit. To identify the systemic and local participation of the bradykinin type 2 receptor (B2R), this was antagonized by Bradyzide (BDZ) during 2 periods: from days 20
Co-culture with endometrial stromal cells enhances the differentiation of human embryonic stem cells into endometrium-like cells
Yu W, et al.
Experimental and Therapeutic Medicine, 10(1), 43-50 (2015)
Gloria Valdés et al.
Reproductive biology and endocrinology : RB&E, 11, 5-5 (2013-01-24)
In humans, trophoblast invasion, vascular remodeling and placental development are critical to determine the fate of pregnancy. Since guinea-pigs (GP) and humans share common pregnancy features including extensive trophoblast invasion, transformation of the uterine spiral arteries and a haemomonochorial placenta
Utero-placental expression of angiotensin-(1-7) and ACE2 in the pregnant guinea-pig
Valdes G, et al.
Reproductive Biology and Endocrinology, 11(1), 5-5 (2013)
Jenny Corthorn et al.
Reproductive biology and endocrinology : RB&E, 5, 27-27 (2007-07-04)
In humans trophoblast invasion and vascular remodeling are critical to determine the fate of pregnancy. Since guinea-pigs share with women an extensive migration of the trophoblasts through the decidua and uterine arteries, and a haemomonochorial placenta, this species was used
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