N6005

β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate

≥94% (HPLC)

• Synonim(y): β-DPNH, β-NADH, DPNH, Diphosphopyridine nucleotide, reduced form, NADH
• Wzór empiryczny (zapis Hilla): C₂₁H₂₇N₇Na₂O₁₄P₂ · xH₂O
• Numer CAS: 606-68-8
• Masa cząsteczkowa: 709.40 (anhydrous basis)
• Numer MDL: MFCD03791273
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 329818659
• NACRES: NA.51

Właściwości

• pochodzenie biologiczne: yeast
• Poziom jakości: 200
• Próba: ≥94% (HPLC); ≥94% (spectrophotometric assay)
• Formularz: powder
• rozpuszczalność: 10 mM NaOH: soluble-100 mg/mL, clear to slightly hazy, slightly yellow to deep greenish-yellow
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• ciąg SMILES: O.[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
• InChI: 1S/C21H29N7O14P2.2Na.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;;1H2/q;2*+1;/p-2/t10-,11-,13-,14-,15-,16-,20-,21-;;;/m1.../s1
• Klucz InChI: FWBNCIFELNNJCX-UHOVGGJYSA-L

Opis

Zastosowanie

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).

As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Działania biochem./fizjol.

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD⁺/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Opakowanie

Packaged by solid weight.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable