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N3908

Sigma-Aldrich

Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit

enhanced validation

affinity isolated antibody, buffered aqueous solution

Synonim(y):

NGFR Antibody - Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit, Ngfr Antibody

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About This Item

Numer MDL:
MFCD00675539
Kod UNSPSC:
51111800
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

200

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

reaktywność gatunkowa

rat

rozszerzona walidacja

functional assay
Learn more about Antibody Enhanced Validation

metody

immunohistochemistry (frozen sections): 1:10,000 using rat brain
indirect immunofluorescence: 1:500 using NGF-treated PC12 cells
microarray: suitable
western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells

numer dostępu UniProt

P07174

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

rat ... Ngfr(24596)

Opis ogólny

Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.
Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.

Immunogen

synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.

Zastosowanie

Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:
  • immunoprecipitation
  • immunocytochemistry
  • immunohistochemistry
  • immunoblotting

Działania biochem./fizjol.

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

D Rebmann et al.
Journal of orthopaedic surgery and research, 15(1), 270-270 (2020-07-19)
Sensory nerve endings in ligaments play an important role for the proprioceptive function. Clinical trials show that the sense of body position does not fully recover in the knee joint after reconstructive surgery of the ruptured anterior cruciate ligament. The
Yan Chen et al.
Medical science monitor : international medical journal of experimental and clinical research, 21, 3608-3615 (2015-11-22)
Alzheimer's disease (AD) is the most common type of dementia. It causes progressive brain disorder involving loss of normal memory and thinking skills. The transplantation of neural stem cells (NSCs) has been reported to improve learning and memory function of
Berith K Tingaker et al.
Reproductive biology and endocrinology : RB&E, 4, 45-45 (2006-08-30)
The uterus is exposed to changes such as enlargement and distension during pregnancy and labor. In these processes and in the process of cervical ripening, proprioceptive information is likely to be of great importance. Therefore, we wanted to study the
Myeongjeong Choo et al.
Nature communications, 8(1), 195-195 (2017-08-05)
Elimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs). A single CF is strengthened whereas the other CFs are eliminated
C Matrone et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(27), 11358-11363 (2009-06-25)
The present study shows that increased Abeta production in hippocampal neurons, due to a failure of NGF signal, induces an unexpected phosphorylation of tyrosine kinase receptor A (TrkA), followed by activation of the phospholipase C gamma (PLCgamma) pathway and neuronal
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