N1628

Novobiocin sodium salt

≥90% (HPLC)

• Synonim(y): Albamycin, Albamycin Sodium, Cathomycin sodium
• Wzór empiryczny (zapis Hilla): C₃₁H₃₅N₂NaO₁₁
• Numer CAS: 1476-53-5
• Masa cząsteczkowa: 634.61
• Beilstein: 3892910
• Numer WE: 216-023-6
• Kod UNSPSC: 51286504
• Identyfikator substancji w PubChem: 24897508
• NACRES: NA.85

Właściwości

• pochodzenie biologiczne: (STREPTOMYCES NIVEUS)
• Próba: ≥90% (HPLC)
• Postać: powder
• warunki przechowywania: (Tightly closed. Dry. )
• kolor: white to yellow
• spektrum działania antybiotyku: Gram-positive bacteria
• Tryb działania: DNA synthesis | interferes; enzyme | inhibits
• temp. przechowywania: 2-8°C
• ciąg SMILES: [Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C
• InChI: 1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
• Klucz InChI: AXOUUAINTJNFRS-UHFFFAOYSA-N

Opis

Opis ogólny

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.

Zastosowanie

Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:

• in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
• in the research on the efficacy of probiotics
• in the research on the efficacy of human monocytes and dendritic cells for T-cell replication

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Działania biochem./fizjol.

Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

Cechy i korzyści

High quality antibiotic suitable for mulitple research applications

Przechowywanie i stabilność

Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive

Inne uwagi

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302,H317,H319
• Zwroty wskazujące środki ostrożności: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves