M168

Methyllycaconitine citrate salt

from Delphinium brownii seeds, ≥96% (HPLC)

• Synonim(y): MLA, [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt
• Wzór empiryczny (zapis Hilla): C₃₇H₅₀N₂O₁₀ · xC₆H₈O₇
• Numer CAS: 112825-05-5
• Masa cząsteczkowa: 682.80 (salt-free basis)
• Numer MDL: MFCD00153837
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24896681
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: Delphinium brownii seeds
• Próba: ≥96% (HPLC)
• kolor: white
• rozpuszczalność: H₂O: 42 mg/mL
• temp. przechowywania: −20°C
• ciąg SMILES: O=C(OC[C@]12[C@@]([C@]3([C@H](CC1)OC)[C@@H]4N(C2)CC)([H])[C@@H]([C@]4(O)[C@]5(O)[C@]6([H])[C@@]3([H])C[C@@]([C@H](C5)OC)([H])[C@@H]6OC)OC)C7=CC=CC=C7N8C([C@@H](C)CC8=O)=O.OC(CC(CC(O)=O)(C(O)=O)O)=O
• InChI: 1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33?,34-,35+,36-,37+;/m0./s1
• Klucz InChI: INBLZNJHDLEWPS-DDIMIZGISA-N

Opis

Zastosowanie

Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:

• to study its effects on inflammatory response in rats post nicotine treatment
• to block the activity of galantamine
• to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats

Działania biochem./fizjol.

Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium. MLA binds to the binding site of neuronal α-bungarotoxin. Low doses of MLA are associated with improvement of cognition in animals.

Cechy i korzyści

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)