L7269
α-Lactalbumin from human milk
≥95% (SDS-PAGE), lyophilized powder
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About This Item
Polecane produkty
pochodzenie biologiczne
human milk
Poziom jakości
Próba
≥95% (SDS-PAGE)
Formularz
lyophilized powder
masa cząsteczkowa
14,070 Da by calculation
stężenie
>75 % protein (UV)
metody
cell migration: suitable
rozpuszczalność
H2O: soluble 10 mg/mL(lit.)
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
human ... LALBA(3906)
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Opis ogólny
α-Lactalbumin (α-LA) is a small, acidic, whey protein that constitutes about 22% of the total proteins in human milk. It is produced by the epithelial cells of the mammary gland. α-LA is made up of two domains, a large α-helical domain, and a small β-sheet domain.
Zastosowanie
α-Lactalbumin (α-LA) has been used as a standard
- to study the partitioning behavior of different monomeric proteins with exposure to amino acids on the protein surface
- to study the interaction between α-LA and cathepsin D
- to study the ability of breast milk fractions to enhance the transepithelial flux of extrinsic iron in colon carcinoma cell line
Działania biochem./fizjol.
α-Lactalbumin (α-LA) forms a complex with lactose synthase within the mammary gland and plays a role in milk production and regulates milk volume. It acts as an essential source for bioactive peptides and essential amino acids such as lysine, tryptophan, branched-chain amino acids, and sulfur-containing amino acids that play a role in an infant′s nutrition. In addition, α-LA has a wide range of applications including a supplement to foster gastrointestinal health and modulate sleep and depression. α-LA also shows therapeutic effects against sarcopenia, seizures, mood disorders, and cancer. It has a Ca2+ binding site that binds with Na+, K+, Mg2+, and Mn2+ and many Zn2+ binding sites.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Complexes of α-lactalbumin with oleic acid show drastically different activities than α-lactalbumin alone, being strongly cytotoxic to tumor cells. The complex is referred to as HAMLET (human alpha-lactalbumin made lethal to tumor cells).
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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K Brew et al.
The Journal of biological chemistry, 242(16), 3747-3749 (1967-08-25)
E A Permyakov et al.
FEBS letters, 473(3), 269-274 (2000-05-20)
Small milk protein alpha-lactalbumin (alpha-LA), a component of lactose synthase, is a simple model Ca(2+) binding protein, which does not belong to the EF-hand proteins, and a classical example of molten globule state. It has a strong Ca(2+) binding site
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