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Merck

L2420

Sigma-Aldrich

Monoclonal Anti-LRP1 antibody produced in mouse

~1.0 mg/mL, clone LRP1-11, purified immunoglobulin, buffered aqueous solution

Synonim(y):

Anti-A2MR, Anti-APOER, Anti-APR, Anti-Apolipoprotein E receptor, Anti-Apolipoprotein receptor, Anti-CD91, Anti-LRP, Anti-Lipoprotein receptor-related protein, Anti-Low density lipoprotein receptor-related protein 1

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

mouse

białko sprzężone

unconjugated

forma przeciwciała

purified immunoglobulin

rodzaj przeciwciała

primary antibodies

klon

LRP1-11, monoclonal

Postać

buffered aqueous solution

masa cząsteczkowa

antigen ~500 kDa

reaktywność gatunkowa

human, rat, mouse

stężenie

~1.0 mg/mL

metody

indirect immunofluorescence: suitable
western blot: 1-2 μg/mL

izotyp

IgG1

numer dostępu UniProt

Warunki transportu

dry ice

temp. przechowywania

−20°C

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

Opis ogólny

Monoclonal Anti-LRP1 (mouse IgG1 isotype) is derived from the hybridoma LRP1-11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human LRP1, conjugated to KLH. LDL receptor family. Low-density lipoprotein (LDL) receptor related protein 1 (LRP1) gene is mapped to human chromosome 12q13.3. LRP1 protein, belongs to the LDL receptor family. LRP1, a single-chain 600 kDa type I transmembrane glycosylated precursor protein, is produced in the endoplasmic reticulum. This protein is proteolytically cleaved in the Golgi complex into two subunits including 85-kDa membrane-bound C-terminal membrane spanning subunit and a noncovalently attached 515-kDa N-terminal subunit.

Specyficzność

Monoclonal Anti-LRP1 recognizes human, rat, and mouse LRP1.

Zastosowanie

Monoclonal Anti-LRP1 antibody produced in mouse has been used in:
  • immunoblotting
  • enzyme linked immunosorbent assay
  • immunofluorescence

Działania biochem./fizjol.

Low density lipoprotein receptor related protein 1 (LRP1) plays an essential role in early stages of embryonic development. It aids in lipoprotein metabolism, proteinase regulation, activation of lysosomal enzymes and cellular entry of viruses and toxins. Additionally, It is also implicated in cell signaling pathways, cell migration, and neurodevelopment. LRP1 interacts with at least 30 different ligands including lipoproteins, proteinases, proteinase-inhibitor complexes, extra cellular matrix (ECM) proteins and various intracellular proteins. Furthermore, LDL receptor related protein 1 also has an ability to associate with bacterial toxins and viruses.

Postać fizyczna

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Przechowywanie i stabilność

Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discard if not used within 12 hours.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Kazuhiro Yamamoto et al.
The Journal of biological chemistry, 289(10), 6462-6474 (2014-01-30)
Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading enzymes. We have recently found that ADAMTS-5
Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption
Zhou G, et al.
Journal of Cell Science, 127(18), 3916-3927 (2014)
Takahisa Kanekiyo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(49), 19276-19283 (2013-12-07)
Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population. Accumulation, aggregation, and deposition of amyloid-β (Aβ) peptides generated through proteolytic cleavage of amyloid precursor protein (APP) are likely initiating events in the pathogenesis of AD.
TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution
Broderick R, et al.
Nature Communications, 6(1), 1-12 (2015)
Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability
Lillis AP, et al.
Journal of Thrombosis and Haemostasis, 3(8), 1884-1893 (2005)

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