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Key Documents

L2262

Sigma-Aldrich

Lipopolysaccharides from Salmonella enterica serotype typhimurium

purified by gel-filtration chromatography

Synonim(y):

LPS

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About This Item

Numer MDL:
Kod UNSPSC:
12352201
NACRES:
NA.25

pochodzenie biologiczne

Salmonella enterica (Serotype typhimurium)

Poziom jakości

Postać

lyophilized powder

oczyszczone przez

gel-filtration chromatography

zanieczyszczenia

<1% Protein

kolor

white to faint yellow

rozpuszczalność

water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow

Warunki transportu

ambient

temp. przechowywania

2-8°C

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Opis ogólny

This product is extracted from Salmonella typhimurium and purified by gel filtration. The source strain is ATCC 7823.

Zastosowanie

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Działania biochem./fizjol.

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Uwaga dotycząca przygotowania

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Inne uwagi

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Jia Lin Ren et al.
Scientific reports, 8(1), 429-429 (2018-01-13)
Inflammation is in a wide spectrum of retinal diseases, causing irreversible blindness and visual impairment. We have previously demonstrated that Green Tea Extract (GTE) is a potent anti-inflammatory agent for anterior uveitis. Here we investigated the anti-inflammatory effect of GTE
Alun C Kirby et al.
Infection and immunity, 72(11), 6390-6400 (2004-10-27)
The location and functional properties of antigen-specific memory T-cell populations in lymphoid and nonlymphoid compartments following DNA immunization or infection with Salmonella were investigated. Epitope-specific CD8+ -T-cell expansion and retention during the memory phase were analyzed for DNA-immunized mice by
Rui F D S Mesquita et al.
Molecular and cellular biology, 34(4), 574-594 (2013-12-04)
The pathways which regulate resolution of inflammation and contribute to positive remodeling of the myocardium following injury are poorly understood. Here we show that protein kinase C epsilon (PKCε) cooperates with the phosphatase calcineurin (CN) to potentiate induction of cardioprotective
Rossella Paolillo et al.
International immunopharmacology, 9(11), 1265-1271 (2009-08-04)
Probiotics, defined as live microbial food supplements which improve the health of the host, have obtained increasing medical importance. In the intestine they may prevent the overgrowth of pathogenic bacteria, increase the resistance of the gut to invasion by pathogens
Varkha Agrawal et al.
Biology of reproduction, 91(5), 119-119 (2014-09-26)
Platelet-activating factor (PAF), a potent phospholipid activator of inflammation that signals through its cognate receptor (platelet-activating factor receptor, PTAFR), has been shown to induce preterm delivery in mice. Toll-like receptors (TLRs) are transmembrane receptors that mediate innate immunity. We have

Produkty

Poznaj strukturę, funkcję i różnorodne zastosowania lipopolisacharydów. Odkryj ich rolę w bakteriach, specyficzność serologiczną i potencjał badawczy.

Powiązane treści

Lipopolisacharyd (LPS) jest głównym składnikiem bakterii Gram-ujemnych, ważnym dla badań mikrobiologicznych.

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