Przejdź do zawartości
Merck
Wszystkie zdjęcia(2)

Key Documents

Inne dokumenty

I9646

Sigma-Aldrich

Interleukin-6 from mouse

IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free

Synonim(y):

mIL-6, IL-6

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(2)

About This Item

Numer MDL:
MFCD01656039
Kod UNSPSC:
12352202
NACRES:
NA.77

pochodzenie biologiczne

mouse

Poziom jakości

200

rekombinowane

expressed in E. coli

Próba

≥97% (SDS-PAGE)

Postać

lyophilized powder

siła działania

0.02-0.2 ng/mL EC50

jakość

endotoxin tested

masa cząsteczkowa

~21.7 kDa

opakowanie

pkg of 5 and 25 μg

metody

cell culture | mammalian: suitable

zanieczyszczenia

≤1.0EU/mg

kolor

white

numer dostępu UniProt

P08505

temp. przechowywania

−20°C

informacje o genach

mouse ... Il6(16193)

Działania biochem./fizjol.

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

Postać fizyczna

Lyophilized from a sterile filtered solution with no additives.

Komentarz do analizy

The biological activity of recombinant mouse IL-6 was measured in a cell proliferation assay using T1165.85.2.1 cells.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Jee Eun Choi et al.
STAR protocols, 3(2), 101389-101389 (2022-05-24)
Metabolic reprogramming is associated with myeloid-derived suppressor cell (MDSC) immunosuppressive function. Here, we outline the process for acquiring MDSCs from human and murine sources for subsequent analysis of fatty acid oxidation, oxidative phosphorylation, and glycolysis using the Seahorse XFe 96
Marrah E Lachowicz-Scroggins et al.
American journal of respiratory cell and molecular biology, 43(6), 652-661 (2010-01-19)
Infection of airway epithelium by rhinovirus is the most common cause of asthma exacerbations. Even in mild asthma, airway epithelium exhibits mucous metaplasia, which increases with increasing severity of the disease. We previously showed that squamous cultures of human airway
Gregory J Tesz et al.
The Journal of biological chemistry, 282(27), 19302-19312 (2007-05-15)
Tumor necrosis factor alpha (TNFalpha) is a cytokine secreted by macrophages and adipocytes that contributes to the low grade inflammation and insulin resistance observed in obesity. TNFalpha signaling decreases peroxisome proliferator-activated receptor gamma and glucose transporter isoform 4 (GLUT4) expression
R P Nordan et al.
Journal of immunology (Baltimore, Md. : 1950), 139(3), 813-817 (1987-08-01)
Plasmacytoma growth factor (PCT-GF), a putative macrophage-derived lymphokine essential for the in vitro viability and proliferation of early generation plasmacytomas, was purified from conditioned medium of the murine macrophage cell line P388D1. The purification of PCT-GF was accomplished by a
Suzanne Speck et al.
PloS one, 9(7), e102390-e102390 (2014-07-30)
While the role of Transforming Growth Factor β (TGF-β) as an intrinsic pathway has been well established in driving de novo differentiation of Th17 cells, no study has directly assessed the capacity of TGF-β signaling initiated within dendritic cells (DCs)
Wyświetl wszystkie powiązane dokumenty

Produkty

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

Lipid Induced Insulin Resistance

Lipid Induced Insulin Resistance

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej