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I1771

Sigma-Aldrich

Interleukin-13 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonim(y):

IL-13

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About This Item

Numer CAS:
148157-34-0
Numer MDL:
MFCD00212209
Kod UNSPSC:
12352202
NACRES:
NA.32

pochodzenie biologiczne

human

Poziom jakości

200

rekombinowane

expressed in E. coli

Próba

≥97% (SDS-PAGE)

Formularz

lyophilized powder

siła działania

<10.000 ng/mL ED50

masa cząsteczkowa

12 kDa

opakowanie

pkg of 10 μg

metody

cell culture | mammalian: suitable

zanieczyszczenia

endotoxin, tested

kolor

white

numer dostępu UniProt

P35225

temp. przechowywania

−20°C

informacje o genach

human ... IL13(3596)

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Działania biochem./fizjol.

IL-13 is known to be overexpressed in glioblastoma tumors and cell lines. Elevated IL-13 expression is also observed in parasitic infections. It stimulates fibrosis in many infectious diseases, and acts as a profibrogenic factor.
Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number
058M4150V
11180308
111M4088V
11111105
091M1088V

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Ji-Yun Lee et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5990-5998 (2015-05-15)
Mucin overproduction is a hallmark of otitis media (OM). Streptococcus pneumoniae is one of the most common bacterial pathogens causing OM. Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens. However, if uncontrolled, excessive mucus contributes significantly
An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum.
Long X et al
PLoS ONE, 10(8), e0135360-e0135360 (2015)
Kihyuk Shin et al.
Clinical and experimental medicine, 15(3), 233-244 (2014-06-14)
The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and
Yan Deng et al.
PloS one, 10(2), e0116682-e0116682 (2015-02-07)
Interleukin-13 (IL-13) is a potent pleiotropic cytokine that is produced by activated CD4 T cells. This study was undertaken to determine the relationship between two IL-13 gene single nucleotide polymorphisms (SNP rs1800925 and SNP rs20541) and the incidence of hepatitis
Qi Liu et al.
The Journal of heart valve disease, 24(4), 496-501 (2016-02-24)
Interleukin (IL)-13 is a major inducer of fibrosis in many chronic infectious diseases, yet few studies have reported its role in valvular fibrosis in patients with rheumatic heart disease (RHD). The study aim was to investigate the role of IL-13
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Produkty

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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