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Merck

G9270

Sigma-Aldrich

γ-Glutamyltranspeptidase from equine kidney

Type VI, 5-12 units/mg solid

Synonim(y):

γ-GT, γ-Glutamyltransferase, (5-Glutamyl)peptide:amino-acid 5-glutamyltransferase, GGTP

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About This Item

Numer CAS:
Numer EC enzymu:
Numer WE:
Numer MDL:
Kod UNSPSC:
12352204
NACRES:
NA.54

pochodzenie biologiczne

equine kidney

Poziom jakości

typ

Type VI

Postać

solid

aktywność właściwa

5-12 units/mg solid

temp. przechowywania

−20°C

Opis ogólny

Gamma-Glutamyltranspeptidase is a heterodimeric enzyme and belongs to the superfamily of N-terminal nucleophile hydrolases.

Zastosowanie

Gamma-glutamyltranspeptidase from equine kidney has been used:

  • to identify the formation of 4-S-Cysteinyltetrodotoxin in the liver of Fugu pardalis
  • as a standard to determine the activity of gamma-glutamyltransferase from human B-cell lymphoma cell lysates
  • to hydrolyze isopeptides to study its effects on tubulin aggregation

Działania biochem./fizjol.

Gamma-Glutamyltranspeptidase participates in glutathione metabolism and it catalyzes the cleavage of gamma-glutamyl compounds, such as glutathione. It also plays a role in the transfer of gamma-glutamyl moiety to amino acids and peptides.

Jakość

Crude

Definicja jednostki

One unit will liberate 1.0 μmole of p-nitroaniline from L-γ-glutamyl-p-nitroanilide per min at pH 8.5 at 25°C.
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inhibitor

Numer produktu
Opis
Cennik

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Karin Bracht et al.
Journal of cancer research and clinical oncology, 133(12), 957-967 (2007-06-15)
The aim of this study was to characterize three new, recently established non-Hodgkin lymphoma cell lines (GUMBUS, DOGUM, and DOGKIT), isolated from patients developing high-clinical resistance to cytotoxic therapy, with respect to sensitivity toward 21 antitumor drugs from different classes
Lawrence M Schopfer et al.
The Journal of biological chemistry, 293(35), 13566-13577 (2018-07-15)
Exposure to organophosphorus toxicants (OP) can have chronic adverse effects that are not explained by inhibition of acetylcholinesterase, the cause of acute OP toxicity. We therefore hypothesized that OP-induced chronic illness is initiated by the formation of organophosphorus adducts on
Gina Boanca et al.
The Journal of biological chemistry, 281(28), 19029-19037 (2006-05-05)
Gamma-glutamyltranspeptidase (gammaGT), a member of the N-terminal nucleophile hydrolase superfamily, initiates extracellular glutathione reclamation by cleaving the gamma-glutamyl amide bond of the tripeptide. This protein is translated as an inactive proenzyme that undergoes autoprocessing to become an active enzyme. The
Mathias Oertli et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(8), 3047-3052 (2013-02-06)
Infection with the gastric bacterial pathogen Helicobacter pylori is typically contracted in early childhood and often persists for decades. The immunomodulatory properties of H. pylori that allow it to colonize humans persistently are believed to also account for H. pylori's
R Foddis et al.
Giornale italiano di medicina del lavoro ed ergonomia, 34(3 Suppl), 565-567 (2013-02-15)
The GGT enzyme, considered for years only as a marker of liver disease and alcohol abuse, has now revealed a risk of death for many causes. Through a molecular exclusion chromatography on FPLC system (Fast Protein Liquid Chromatography), it is

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