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Dokumenty

E5008

[D-Ala²]-Leucine enkephalin

Name: [<SC>D</SC>-Ala<SUP>2</SUP>]-Leucine enkephalin
Brand: SIGMA

≥97% (HPLC), suitable for ligand binding assays

Synonim(y):

Tyr-D-Ala-Gly-Phe-Leu

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About This Item

Wzór empiryczny (zapis Hilla):

C₂₉H₃₉N₅O₇

Numer CAS:

64963-01-5

Masa cząsteczkowa:

569.65

Numer WE:

265-291-0

Numer MDL:

MFCD00076409

Kod UNSPSC:

12352209

Identyfikator substancji w PubChem:

24894597

NACRES:

NA.26

product name

[D-Ala²]-Leucine enkephalin, ≥97% (HPLC)

Poziom jakości

200

Próba

≥97% (HPLC)

Postać

powder

metody

ligand binding assay: suitable

kolor

white

temp. przechowywania

−20°C

ciąg SMILES

CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(C)NC(=O)C(N)Cc2ccc(O)cc2)C(O)=O

InChI

1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)

Klucz InChI

ZHUJMSMQIPIPTF-UHFFFAOYSA-N

Powiązane kategorie

Amino Acids

Biochemicals

Cell Culture Supplements & Reagents

Amino Acid Sequence

Tyr-Ala-Gly-Phe-Leu

Działania biochem./fizjol.

The Enkephalin amid peptide [D-Ala2]-Leucine enkephalin ((DADLE), a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin analog used to study the signaling pathway of delta opioid receptors.

Inne uwagi

Potent, long-acting Leu-enkephalin analog that is resistant to enzymatic degradation

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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Determination of enkephalin peptides by nonaqueous capillary electrophoresis with electrochemical detection.

Arndt Psurek et al.

Electrophoresis, 27(5-6), 1199-1208 (2006-03-09)

Nonaqueous capillary electrophoresis with electrochemical detection (NACE-ED) was applied to the analysis of enkephalin peptides. The effect of different buffer compositions on the electrophoretic behavior of methionine enkephalin, leucine enkephalin, and [D-Ala2]-leucine enkephalin was studied. Separation of the protonated and

Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.

A M Ostermeier et al.

Anesthesiology, 93(4), 1053-1063 (2000-10-06)

The mechanism underlying the depressant effect of opioids on neuronal activity within the neocortex is still not clear. Three modes of action have been suggested: (1) inhibition by activation of postsynaptic potassium channels, (2) interaction with postsynaptic glutamate receptors, and

Leucine enkephalin effects on paracellular and transcellular permeation pathways across brain microvessel endothelial cell monolayers.

S E Thompson et al.

Journal of cardiovascular pharmacology, 24(5), 818-825 (1994-11-01)

Leucine enkephalin (YGGFL) effects on markers for transcellular and paracellular permeation across the blood-brain barrier (BBB) were investigated in vitro with bovine brain microvessel endothelial cell (BMEC) monolayers in primary culture. Intact YGGFL, but not metabolites of YGGFL, stimulated BMEC

Direct excitatory opiate effects mediated by non-synaptic actions on rat medial vestibular neurons.

Y Lin et al.

European journal of pharmacology, 262(1-2), 99-106 (1994-09-01)

Opiates increase firing of rat medial vestibular nucleus neurons. We have attempted to determine the mechanism of these excitatory opiate actions by extracellular recording of neuronal activity with ionophoretic application of opiate agonists and bath application of antagonists. The spontaneous

Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation.

A R Burt et al.

The Biochemical journal, 320 ( Pt 1), 227-235 (1996-11-15)

Rat-1 fibroblasts were transfected with a cDNA encoding the mouse delta opioid receptor. Two separate clones, D2 (which expressed some 6 pmol of the receptor/mg of membrane protein) and DOE (which expressed some 0.2 pmol/mg of membrane protein), were examined

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