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D6134
2-Deoxy-D-glucose
≥99% (GC), crystalline
Synonim(y):
2-Deoxy-D-arabinohexose
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About This Item
Wzór empiryczny (zapis Hilla):
C6H12O5
Numer CAS:
Masa cząsteczkowa:
164.16
Beilstein:
1723331
Numer WE:
Numer MDL:
Kod UNSPSC:
12352201
Identyfikator substancji w PubChem:
NACRES:
NA.25
Polecane produkty
pochodzenie biologiczne
synthetic (organic)
Próba
≥99% (GC)
Formularz
crystalline
metody
gas chromatography (GC): suitable
kolor
white
mp
146-147 °C (lit.)
rozpuszczalność
H2O: soluble 330 mg/mL, clear, colorless
temp. przechowywania
2-8°C
ciąg SMILES
OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
InChI
1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
Klucz InChI
VRYALKFFQXWPIH-PBXRRBTRSA-N
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Zastosowanie
2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Działania biochem./fizjol.
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.
Uwaga dotycząca przygotowania
A further purification of the Grade II material by recrystallization.
Inne uwagi
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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