C7870

Chalcone 4 hydrate

≥98% (HPLC)

• Synonim(y): (E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate
• Wzór empiryczny (zapis Hilla): C₁₆H₁₃ClO₃ · xH₂O
• Numer CAS: 1202866-96-3
• Masa cząsteczkowa: 288.73 (anhydrous basis)
• Numer MDL: MFCD12912407
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 329775154
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Postać: solid
• warunki przechowywania: protect from light
• kolor: yellow
• rozpuszczalność: DMSO: >20 mg/mL
• temp. przechowywania: −20°C
• ciąg SMILES: O.COc1cc(ccc1O)\C=C\C(=O)c2ccc(Cl)cc2
• InChI: 1S/C16H13ClO3.H2O/c1-20-16-10-11(3-9-15(16)19)2-8-14(18)12-4-6-13(17)7-5-12;/h2-10,19H,1H3;1H2/b8-2+;
• Klucz InChI: PXVQKTVKTBMRIW-VOKCZWNHSA-N

Opis

Działania biochem./fizjol.

Chalcone 4 is a potent, selective inhibitor of the chemokine CXCL12 via direct binding. It is also a small molecule anti-ligand (or neutraligand) of CXCR4 and CXCR7. The chemokine CXCL12 (stromal cell-derived factor-1) and its receptors play pivotal roles in inflammatory responses, normal vascular and neuronal development, as well as in infectious diseases and cancer. Chalcone 4 binds to and activates the chemokine receptors CXCR4 and CXCR7 and stimulates a rapid receptor-mediated intracellular calcium mobilization and signaling through a Pertussis toxin sensitive Gi protein. Chalcone 4 potently and selectively inhibits CXCL12 binding to CXCR4 and CXCR7, and consequent CXCL12-evoked calcium cellular responses. Chalcone 4 binds to the chemokine CXCL12, but not to its receptors.

Cechy i korzyści

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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