Wszystkie zdjęcia(2)
Kluczowe dokumenty
C5438
8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt
≥95% (HPLC), powder
Synonim(y):
8-pCPT-cGMP, pCPT-cGMP
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Wzór empiryczny (zapis Hilla):
C16H14ClN5NaO7PS
Numer CAS:
Masa cząsteczkowa:
509.79
Numer MDL:
Kod UNSPSC:
41106305
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
Poziom jakości
Próba
≥95% (HPLC)
Formularz
powder
kolor
white
rozpuszczalność
H2O: 25 mg/mL
temp. przechowywania
−20°C
ciąg SMILES
[Na+].NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5COP([O-])(=O)O[C@H]5[C@H]4O)C(=O)N1
InChI
1S/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1
Klucz InChI
REEQGIQRCDWDRA-ZBMQJGODSA-M
Powiązane kategorie
Zastosowanie
8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt has been used to activate GMP-dependent protein kinase (PKG) in vascular smooth muscle cells (VSMCs).
Działania biochem./fizjol.
Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.
Cechy i korzyści
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Ta strona może zawierać tekst przetłumaczony maszynowo.
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Wybierz jedną z najnowszych wersji:
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Klienci oglądali również te produkty
![[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/215/222/82da3633-80ea-463d-8b55-e99fb8e442e0/640/82da3633-80ea-463d-8b55-e99fb8e442e0.png)
Hypoxic depression of PKG-mediated inhibition of serotonergic contraction in ovine carotid arteries.
Richard B Thorpe et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R734-R743 (2013-03-01)
Chronic hypoxia attenuates soluble guanylate cyclase-induced vasorelaxation in serotonin (5-HT)-contracted ovine carotid arteries. Because protein kinase G (PKG) mediates many effects of soluble guanylate cyclase activation through phosphorylation of multiple kinase targets in vascular smooth muscle, we tested the hypothesis
B E VanUffelen et al.
Biochemical pharmacology, 56(8), 1061-1063 (1998-10-17)
In previous experiments, it was shown that migration of electropermeabilized human neutrophils induced by a combination of cGMP and cAMP markedly lower relative to that induced by cGMP or cAMP alone. However, when cGMP was replaced with 8-(para-chlorophenylthio-guanosine-3',5'-cyclic monophosphate (8-pCPT-cGMP)
Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis
Pallero MA, et al.
Journal of Vascular Research, 47(4), 309-322 (2010)
J Y Wei et al.
Journal of molecular neuroscience : MN, 10(1), 53-64 (1998-05-20)
Cyclic nucleotide-gated (CNG) channels are expressed in many cell types in both the nervous system and nonexcitable tissues. In order to understand the roles of cGMP-gated channels, and to distinguish actions of cGMP mediated through CNG channels from those through
M Suhasini et al.
Molecular and cellular biology, 18(12), 6983-6994 (1998-11-20)
Agents which increase the intracellular cyclic GMP (cGMP) concentration and cGMP analogs inhibit cell growth in several different cell types, but it is not known which of the intracellular target proteins of cGMP is (are) responsible for the growth-suppressive effects
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej