D2534

cis-4,7,10,13,16,19-Docosahexaenoic acid

≥98%

• Synonim(y): DHA
• Wzór empiryczny (zapis Hilla): C₂₂H₃₂O₂
• Numer CAS: 6217-54-5
• Masa cząsteczkowa: 328.49
• Beilstein: 1715505
• Numer MDL: MFCD00065722
• Kod UNSPSC: 12352211
• Identyfikator substancji w PubChem: 24893696
• NACRES: NA.25

Właściwości

• pochodzenie biologiczne: algae
• Próba: ≥98%
• Formularz: liquid
• grupa funkcyjna: carboxylic acid
• typ lipidu: omega FAs
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
• InChI: 1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
• Klucz InChI: MBMBGCFOFBJSGT-KUBAVDMBSA-N

Opis

Opis ogólny

Docosahexaenoic acid (DHA) is abundantly present in the brain.

Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid with 22 carbons and six double bonds, the first double bond occurring at position three from the methyl terminus (22:6 n-3). It is a component of lipid membranes and myelin sheath.

Zastosowanie

cis-4,7,10,13,16,19-Docosahexaenoic acid has been used:

• as a component in Dulbecco′s modified Eagle medium (DMEM) for culturing cells to perform docosahexaenoic acid (DHA) treatment
• to study its impact on human induced pluripotent stem cell (iPSC)-derived neuronal at a molecular and cellular level
• in MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay to study its cytotoxic effects on three human hepatocellular carcinoma (HCC) cell lines (HepG2, Hep3B, Huh7)

Działania biochem./fizjol.

Docosahexaenoic acid (DHA) participates in the growth and physiology of the central nervous system. It regulates adult neurogenesis and neuroplasticity. DHA plays a key role in fetal brain development. It may exhibit antioxidant and anti-inflammatory properties. DHA plays a role in the regulation of cell membrane fluidity. It plays a vital role in several brain development processes, including neurotransmitter release, gene expression, myelination, neuroinflammation, and neuronal differentiation. DHA possesses an anticancer effect in several types of cancer.

Docosahexaenoic acid (DHA) serves as a precursor for signaling molecules such as prostaglandins and eicosanoids.

Opakowanie

Sealed ampule.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): 143.6 °F - closed cup
• Temperatura zapłonu (°C): 62 °C - closed cup
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)