B7880

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt

≥97% (HPLC), powder

• Synonim(y): 8-Br-cAMP
• Wzór empiryczny (zapis Hilla): C₁₀H₁₀BrN₅NaO₆P
• Numer CAS: 76939-46-3
• Masa cząsteczkowa: 430.08
• Beilstein: 7739743
• Numer MDL: MFCD00005844
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 24278020
• NACRES: NA.77

Właściwości

• Poziom jakości: 200
• Próba: ≥97% (HPLC)
• Postać: powder
• kolor: off-white
• rozpuszczalność: H₂O: 100 mg/mL
• temp. przechowywania: −20°C
• ciąg SMILES: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12
• InChI: 1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• Klucz InChI: DMRMZQATXPQOTP-GWTDSMLYSA-M

Opis

Opis ogólny

8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.

Zastosowanie

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:

• to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
• used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
• in superfusion medium for head kidneys stimulation

Działania biochem./fizjol.

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

Cechy i korzyści

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Inne uwagi

Membrane-permeable cAMP analog.

Przestroga

Sensitive to light and moisture.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)