C3912

8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt

≥97.0% (HPLC), powder

• Synonim(y): pCPT-cAMP
• Wzór empiryczny (zapis Hilla): C₁₆H₁₄ClN₅NaO₆PS
• Numer CAS: 93882-12-3
• Masa cząsteczkowa: 493.79
• Numer WE: 299-413-9
• Numer MDL: MFCD00057683
• Kod UNSPSC: 41106305
• Identyfikator substancji w PubChem: 24278024
• NACRES: NA.77

Właściwości

• Poziom jakości: 200
• Próba: ≥97.0% (HPLC)
• Postać: powder
• kolor: white
• rozpuszczalność: H₂O: 25 mg/mL
• temp. przechowywania: −20°C
• ciąg SMILES: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12
• InChI: 1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1
• Klucz InChI: YIJFVHMIFGLKQL-DNBRLMRSSA-M
• informacje o genach: human ... PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)

Opis

Zastosowanie

8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt has been used:

• to upregulate cellular cholesterol pump (adenosine triphosphate- (ATP-) binding cassette (ABC) transporter-1, ABCA-1)
• in glucose production assay
• to stimulate cystic fibrosis transmembrane conductance regulator (CFTR) channel in airway epithelia

Działania biochem./fizjol.

Membrane permeable cAMP analog. Used as a selective activator of cAMP dependent protein kinase (PKA). Inhibits cGMP-dependent phosphodiesterase and, at higher concentrations, inhibits cAMP-dependent phosphodiesterase. Inhibits phosphoinositide hydrolysis and secretion stimulated by n-formyl-Met-Leu-Phe but not platelet-activating factor in leukocytes. Renders HL-60 cells more resistant to NO-induced DNA damage.

Cechy i korzyści

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)