C2917

Corticotropin Releasing Factor Antagonist

≥97% (HPLC)

• Synonim(y): α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)
• Wzór empiryczny (zapis Hilla): C₁₆₆H₂₇₄N₄₆O₅₃S₂
• Numer CAS: 99658-03-4
• Masa cząsteczkowa: 3826.36
• Numer MDL: MFCD00081543
• Kod UNSPSC: 51111800
• NACRES: NA.32

Właściwości

• Poziom jakości: 200
• Próba: ≥97% (HPLC)
• Postać: powder
• temp. przechowywania: −20°C
• informacje o genach: human ... CRH(1392) ; mouse ... CRH(12918) ; rat ... CRH(81648)

Opis

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2

Działania biochem./fizjol.

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

Inne uwagi

Lyophilized from 0.1% TFA in H2O

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)